{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:25:11Z","timestamp":1784179511849,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Psoriasis, a chronic inflammatory skin disease, involves dysregulated immune responses and keratinocyte hyperproliferation. The role of salt\u2010inducible kinase 2 (SIK2) in modulating interleukin\u201023 (IL\u201023) secretion via C\u2013X\u2013C motif chemokine ligand 5 (CXCL5) in neutrophils has not been fully explored. We combined\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    approaches to examine SIK2's role in an imiquimod (IMQ)\u2010induced psoriasis model and activated neutrophils. Mice underwent intradermal injections of lentiviruses overexpressing SIK2, CXCL5, or both, while\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments involved transfecting activated neutrophils with these constructs. Assessments included ear thickness, cellular and neutrophil infiltration through histological and immunofluorescence techniques, and analysis of gene and protein expressions via quantitative real\u2010time PCR (qRT\u2010PCR), immunohistochemistry (IHC), and Western blot. Additionally, cell viability, proliferation, and cytokine levels in\n                    <jats:italic>N<\/jats:italic>\n                    \u2010formylmethionyl\u2010leucyl\u2010phenylalanine (fMLF) treated neutrophils were evaluated using cell\u2010counting kit\u20108 (CCK8), 5\u2010ethynyl\u20102\u2032\u2010deoxyuridine (EdU) incorporation, and Enzyme\u2010Linked Immunosorbent Assay (ELISA). Overexpression of SIK2 significantly reduced ear thickness, cellular and neutrophil infiltration, IL\u20101\u03b2, tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), CXCL5, IL\u201023 and phosphorylated Yes\u2010associated protein (p\u2010YAP) levels, and increased SIK2 levels in IMQ mice model, but overexpression of CXCL5 reversed these effects.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , SIK2 overexpression resulted in reduced cell viability and proliferation, with corresponding reductions in IL\u20101\u03b2, IL\u201017, IL\u201023, and Matrix Metallopeptidase 9 levels, whereas overexpression of CXCL5 reversed these effects. Our findings suggest that SIK2 acts as a critical modulator in psoriasis by influencing CXCL5\u2010mediated IL\u201023 secretion in neutrophils, underscoring the potential of SIK2 as a therapeutic target to alleviate the inflammatory responses in psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/imcb.70105","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:32:06Z","timestamp":1774258326000},"page":"419-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring\n                    <scp>SIK2<\/scp>\n                    \u2010\n                    <scp>CXCL5<\/scp>\n                    interactions in neutrophils: A novel mechanism for modulating\n                    <scp>IL<\/scp>\n                    \u201023 and psoriasis progression"],"prefix":"10.1111","volume":"104","author":[{"given":"Yadi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhusheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3538-5430","authenticated-orcid":false,"given":"Aihua","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312793"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.06.019"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094983"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0692-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02376"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.04.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.05.032"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S416417"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0648-1"},{"key":"e_1_2_9_13_1","first-page":"12626","article-title":"The 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