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Understanding GC biology remains a key research focus for promoting lifelong health. In this annual update, we highlight several influential studies on GC biology published in 2025 (Fig.\u00a01). Space constraints prevent us from discussing in depth all published work.<\/jats:p>","DOI":"10.1111\/imcb.70131","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:35:41Z","timestamp":1778801741000},"page":"609-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Highlights of 2025: advances in germinal centers"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3417-1484","authenticated-orcid":false,"given":"Louise MC","family":"Webb","sequence":"first","affiliation":[{"name":"Babraham Institute  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-1996","authenticated-orcid":false,"given":"Michelle A","family":"Linterman","sequence":"additional","affiliation":[{"name":"Babraham Institute  Cambridge UK"},{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-120419-022408"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.11.033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08728-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08687-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adu3718"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63291-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115977"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.02.021"},{"key":"e_1_2_9_10_1","first-page":"1821","article-title":"Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity","volume":"26","author":"Dalit L","year":"2024","journal-title":"Immunology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adr0517"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2025.02.001"},{"key":"e_1_2_9_13_1","first-page":"2400","article-title":"T cell\u2010derived IFN\u2010\u03b3 suppresses T follicular helper cell differentiation and antibody responses","volume":"44","author":"Sala E","year":"2025","journal-title":"Immunology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02125-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.187271"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02179-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adr6896"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.115334"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.11.023"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.10.008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adw7499"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.04.005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.10.022"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2416855122"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2421724122"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-02064-9"}],"container-title":["Immunology &amp; 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