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This study investigates the molecular mechanisms underlying the therapeutic effects of licorice\u2013ginger decoction (GGD) in experimental models relevant to arthritis\u2010associated lung fibrosis. Utilizing network pharmacology, transcriptomic sequencing, and molecular docking analyses, we identified the STAT1\/ICAM1\/IL\u201017A signaling pathway as crucial for GGD efficacy. Experimental validation in both cellular and murine models demonstrated that GGD markedly alleviated body weight loss, reduced arthritis severity, and improved pulmonary pathological injury under inflammatory arthritis conditions. Mechanistic analyses revealed direct binding of Kae and QR to STAT1\/ICAM1, leading to IL\u201017A inhibition and mitigation of epithelial\u2013mesenchymal transition (EMT) and fibroblast activation. Notably, overexpression of STAT1 attenuated the therapeutic effects of GGD. This study provides mechanistic insights into the anti\u2010inflammatory and antifibrotic effects of GGD in experimental models relevant to arthritis\u2010associated lung fibrosis and offers a potential framework for future mechanistic studies and translational research of classical Chinese formulations.<\/jats:p>","DOI":"10.1111\/imcb.70136","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:40:24Z","timestamp":1785937224000},"page":"794-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular insights into the anti\u2010inflammatory and antifibrotic effects of licorice\u2013ginger decoction in experimental models of inflammatory arthritis\u2010associated lung 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