{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:18Z","timestamp":1788509598404,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study investigates the role of CIT gene in uterine corpus endometrial carcinoma (UCEC) progression, focusing on its regulation by m6A methylation. Bioinformatics and experimental analyses (EdU, colony formation assay, Dot blot, MeRIP\u2010PCR, RNA pull\u2010down, qRT\u2010PCR, Western Blotting, apoptosis assay) revealed that CIT was significantly overexpressed in UCEC. Mechanistically, we found that the m6A writer RBM15\u2010mediated CIT mRNA methylation, which was then recognized by the reader IGF2BP1 to enhance CIT mRNA stability and expression. Consequently, this m6A\u2010mediated upregulation of CIT inhibited the Hippo signaling pathway, ultimately suppressing apoptosis and promoting malignant proliferation in UCEC. These findings elucidated a novel RBM15\/IGF2BP1\u2010CIT\u2010Hippo axis, providing new theoretical insights and potential therapeutic targets for UCEC.<\/jats:p>","DOI":"10.1111\/imcb.70152","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:06:00Z","timestamp":1786107960000},"page":"818-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The N6\u2010Methyladenosine\u2010Modified CIT Promotes Uterine Corpus Endometrial Carcinoma Progression by Inhibiting the Hippo Signaling Pathway"],"prefix":"10.1111","volume":"104","author":[{"given":"Yuehong","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Gynaecology Affiliated Jinhua Hospital, Zhejiang University School of Medicine  Jinhua Zhejiang China"},{"name":"Department of Gynaecology Jinhua Maternal and Child Health Care Hospital  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Affiliated Jinhua Hospital, Zhejiang University School of Medicine  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiQun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Jinhua Maternal and Child Health Care Hospital  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Affiliated Jinhua Hospital, Zhejiang University School of Medicine  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8476-9967","authenticated-orcid":false,"given":"Xiaoyan","family":"Fu","sequence":"additional","affiliation":[{"name":"Medical Molecular Biology Laboratory, Medical College Jinhua University of Vocational Technology  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.2819"},{"key":"e_1_2_12_3_1","volume-title":"StatPearls","author":"Mahdy H.","year":"2025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0006"},{"key":"e_1_2_12_5_1","first-page":"221","article-title":"Cancer Incidence and Mortality in China, 2022","volume":"46","author":"Zheng R. S.","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30828"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.12.269"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01204-7"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10490-x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/28873"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028456"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109830"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.944000"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00571-w"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.15698\/cst2021.11.258"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz013"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14249"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2858"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0883"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0070-z"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.05.04.652102"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-04-0194"},{"key":"e_1_2_12_24_1","first-page":"1815","article-title":"High Expression of Citron Kinase Predicts Poor Prognosis of Prostate Cancer","volume":"19","author":"Liu J.","year":"2020","journal-title":"Oncology Letters"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.628547"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01856-1"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107311"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21514-8"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01782-2"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00450-x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13046-021-01871-4","article-title":"RBM15 Facilitates Laryngeal Squamous Cell Carcinoma Progression by Regulating TMBIM6 Stability Through IGF2BP3 Dependent","volume":"40","author":"Wang X.","year":"2021","journal-title":"Journal of Experimental & Clinical Cancer Research: CR"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2021.0226"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49345"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c00107"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imcb.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:28:41Z","timestamp":1788506921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,7]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/imcb.70152"],"URL":"https:\/\/doi.org\/10.1111\/imcb.70152","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,7]]},"assertion":[{"value":"2025-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}