{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:59:30Z","timestamp":1790848770980,"version":"4.1.0"},"reference-count":155,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lysosomes are central regulators of cellular homeostasis, integrating catabolic and anabolic reactions to sustain metabolism. In cancer, however, lysosomal function is not merely upregulated but selectively rewired into distinct, context\u2010dependent states that actively drive tumor immune evasion. This review proposes a conceptual framework linking metabolic, oxidative, oncogenic, and inflammatory pressures to six dominant lysosomal rewiring programs. Chronic nutrient deprivation and hypoxia activate AMPK\u2010ULK1 and HIF signaling, promoting TFEB\/TFE3\u2010dependent lysosomal biogenesis, hyper\u2010acidification, and autophagosome\u2013lysosome fusion, collectively degrading immune effectors such as IL\u20101\u03b2 and MHC complexes and impairing T\u2010cell priming. Disseminated tumor cells exploit TPC2\u2010mediated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling and GLS1\u2010dependent metabolism to buffer oxidative stress and support metastatic colonization, while dysregulated PI3K\u2010AKT\u2013mTOR and MYC signaling drive lysosomal peripheralization and lysosomal biogenesis through Arl8b\u2010BORC\u2010kinesin complexes, facilitating cathepsin\u2010mediated exocytosis and MHC\u2010I degradation. Chronic inflammation, sustained by tumor\u2010associated macrophages, myeloid\u2010derived suppressor cells, and IL\u20106\/IL\u201010 gradients, further reinforce immune suppression. Beyond mechanisms, we also assess the translational readiness of the implicated molecular mediators, distinguishing those with established pharmacological outcomes, such as PI3K\u2010AKT\u2013mTOR inhibitors and repurposed chloroquine\/hydroxychloroquine, from mediators that remain strictly preclinical, including TPC2, Arl8b\u2010BORC, and CMTM6\/DHHC3, or that are currently undruggable, such as TFEB\/TFE3. By framing lysosomes as state\u2010specific orchestrators of immune escape rather than uniform stress organelles, this review offers a mechanistic and translational roadmap for developing lysosome\u2010directed strategies to restore anti\u2010tumor immunity.\n                  <\/jats:p>","DOI":"10.1111\/imcb.70157","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:46:03Z","timestamp":1786682763000},"page":"848-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lysosomal Rewiring Perpetuates Tumor Immune Evasion in Cancer"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-4798","authenticated-orcid":false,"given":"Nawal","family":"Al\u2010Hoshani","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6639-3876","authenticated-orcid":false,"given":"Asad","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Veterinary and Animal Sciences  Lahore Pakistan"},{"name":"Institute of Biochemistry and Biotechnology (IBBt) University of Veterinary and Animal Sciences  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7930-7782","authenticated-orcid":false,"given":"Muhammad Muddassir","family":"Ali","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biotechnology (IBBt) University of Veterinary and Animal Sciences  Lahore Pakistan"},{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine Cornell University  Ithaca New\u00a0York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-4710","authenticated-orcid":false,"given":"Rania Ali El Hadi","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Princess Nourah Bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010025\u201000873\u2010w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00676-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00778-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.091181"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-019-0079-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13388"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1308070"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13050459"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.15698\/cst2017.10.103"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14124"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01332-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153627"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300850"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01625"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216796120"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00023-18"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-020-00489-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34428-w"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2229-5"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70295"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0507"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1324045"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58528-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1470729"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00938"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112515"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13051007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00396"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2452149"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01719"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103267"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1056947"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.10.009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593428"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541264.2016.1264353"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3114"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2217425120"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125407"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174447"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022111241"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1740"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002790"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.655731"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10823"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI191940"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-0246-7"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00848"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091492"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0318-2"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0227-y"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030678"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-01030-w"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13287"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-022-00477-y"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2015"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00302"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.011"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.77"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.642494"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1384733"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17111747"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23643"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189152"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01388-x"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0908-z"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2024.06.001"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1177"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.07.013"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.07.008"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-11329-x"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636568"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12138"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02581"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.292"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.012"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0180"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13694"},{"issue":"36","key":"e_1_2_9_80_1","first-page":"E8479","article-title":"Metastatic Cells Are Preferentially Vulnerable to Lysosomal Inhibition","volume":"115","author":"Morgan M. J.","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100844108"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.05.020"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0297-6"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0944-z"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10102752"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797858"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081694"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48794-x"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1847462"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01039-5"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304790110"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-022-00958-5"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1320414"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6908"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1154146"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09545-3"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaf163"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.819128"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.02.011"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2016.02.009"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1407406"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.250647.114"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/10518"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/370482"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12587"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.774103"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083716"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04912-8"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2204"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1571"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0375-6"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/21592799.2015.1086501"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045910"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320318110"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc4027"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0834-6"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01339-9"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-041015-055523"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.11.001"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/27694127.2024.2305594"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70331"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2044-4"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-698"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45851"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2011.02.009"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2010.01.001"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8832"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0283"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2021.05.006"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00108"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.5.2065"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211069012"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.035"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0127-6"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.010"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.014"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1612"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000543"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118715303289859240214103350"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0313-5"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11009-8"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307-010-0052-5"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-025-03145-7"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102534"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases10030035"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-026-02572-2"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.04.001"},{"key":"e_1_2_9_148_1","unstructured":"L.Yu J.Wei andP.Liu \u201cSeminars in Cancer Biology \u201d(2022)."},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142317"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010366"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1586257"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.3390\/futurepharmacol2040028"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020945"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612931"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.05.001"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-025-00784-0"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.70157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imcb.70157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imcb.70157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:42:26Z","timestamp":1790847746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imcb.70157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":155,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/imcb.70157"],"URL":"https:\/\/doi.org\/10.1111\/imcb.70157","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2026-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}