{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T02:56:13Z","timestamp":1717383373301},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyponatraemia in liver failure is associated with increased morbidity and mortality. Improving serum sodium in liver failure has been observed in patients receiving terlipressin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the response of hyponatraemia in patients with liver failure to terlipressin using comparative retrospective analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three patients received terlipressin for hyponatraemia after failed conservative management (median age 52 years (27\u201367), model for end\u2010stage liver disease score 28 (16\u201338)). The median therapy was 7 days (1\u201327), with an average total dose of 25\u2009mg (4\u201390) and a mean follow up of 51 days (5\u20131248). These patients were compared with 11 hyponatraemic patients managed conservatively during the same period with comparable age, baseline serum sodium and follow up. After 1 week of terlipressin therapy, serum sodium increased from a median of 120 (115\u2013128) to 129\u2009mmol\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> (121\u2013144) (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> &lt; 0.001), and at the end of terlipressin therapy, the serum sodium had increased significantly to 131\u2009mmol\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> (120\u2013148) (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> &lt; 0.001). In comparison, in the conservatively managed group, the serum sodium did not increase significantly from the baseline of 123 (117\u2013127) mmol\/<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>. Adverse events occurred in 26% of patients receiving terlipressin, which predominantly pulmonary oedema. Importantly, more hyponatraemic patients treated with terlipressin (48%) were alive compared with the conservative group (18%), despite the latter having a significantly lower baseline median <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score of 21 (16\u201330) (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.008). Moreover, the transplant\u2010free survival was higher in the terlipressin (30%) compared with the conservative group (0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Terlipressin is effective in treating hyponatraemia in liver failure. Importantly, terlipressin use results in better transplant\u2010free survival but also more adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12032","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T14:32:03Z","timestamp":1353681123000},"page":"240-246","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Terlipressin therapy for moderate\u2010to\u2010severe hyponatraemia in patients with liver failure"],"prefix":"10.1111","volume":"43","author":[{"given":"E.","family":"Prakoso","sequence":"first","affiliation":[{"name":"AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital"},{"name":"Liver Immunobiology Laboratory Centenary Institute  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Royal Prince Alfred Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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