{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:41:40Z","timestamp":1761561700047},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Background\/Aim<\/jats:title>To determine short\u2010 and long\u2010term outcomes among a cohort of patients with variceal haemorrhage at a tertiary referral centre, and to determine the predictive value of the model for end\u2010stage liver disease (MELD<\/jats:styled-content>) score for mortality in these patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Prospective database hospital audit that captured patients who presented with or were transferred with variceal haemorrhage between 2004 and 2008, and a retrospective review of long\u2010term outcomes. Patients who presented to or were transferred to J<\/jats:styled-content>ohn H<\/jats:styled-content>unter H<\/jats:styled-content>ospital, a tertiary referral hospital, with confirmed variceal bleeding were included. The main outcome measures were in\u2010hospital, 6 weeks and end\u2010of\u2010audit mortality. We also recorded cause, location and degree of planning surrounding the deaths in this patient group. We analysed the MELD<\/jats:styled-content> score for patients with complete survival data.<\/jats:p><\/jats:sec>Results<\/jats:title>We recorded 93 episodes of variceal haemorrhage from 78 unique patients during the initial study period. The in\u2010hospital mortality, 6 weeks mortality and end\u2010of\u2010audit mortality were 2.6, 9.0 and 59, respectively, and median survival time was 3.2 years (95% confidence interval 0.0, 6.1). The most frequent cause of death was related to complications of end\u2010stage liver disease at 74%, followed by variceal bleeding (19%) and unknown (6%). A C<\/jats:styled-content>ox proportional hazard model showed that the risk of mortality is increased by 1.06 (1.01\u20131.11) for each unit increase in MELD<\/jats:styled-content> score.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Short\u2010term outcomes for patients with variceal bleeding continue to improve, but long\u2010term prognosis remains guarded and should prompt further emphasis on advanced care planning to optimise patient care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12037","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T14:32:22Z","timestamp":1353681142000},"page":"234-239","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short\u2010 and long\u2010term outcomes for patients with variceal haemorrhage in a tertiary hospital"],"prefix":"10.1111","volume":"43","author":[{"given":"M.","family":"Halland","sequence":"first","affiliation":[{"name":"Department of Gastroenterology John Hunter Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Ansley","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology John Hunter Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Discipline of Clinical Pharmacology University of Newcastle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology and Biostatistics University of Newcastle Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Inder","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology and Biostatistics University of Newcastle Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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