{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:39:36Z","timestamp":1722929976203},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Chronic hepatitis B<\/jats:styled-content> (HBV<\/jats:styled-content>) and cirrhosis are major risk factors for hepatocellular carcinoma (HCC<\/jats:styled-content>). The proportion and characteristics of cases with cirrhosis are not well documented.<\/jats:p><\/jats:sec>Aim<\/jats:title>Our aim was to compare demographic, viral and tumour characteristics of HBV<\/jats:styled-content>\u2010associated HCC<\/jats:styled-content> in an A<\/jats:styled-content>ustralian cohort, in patients with and without cirrhosis.<\/jats:p><\/jats:sec>Methods<\/jats:title>Existing HCC<\/jats:styled-content> databases at six M<\/jats:styled-content>elbourne teaching hospitals were reviewed for cases associated with HBV<\/jats:styled-content>. Patient demographics, HBV<\/jats:styled-content> viral characteristics, presence of cirrhosis, serum alpha\u2010fetoprotein and tumour size were assessed. Mode of diagnosis was recorded through surveillance or symptoms, and treatment was either palliative, percutaneous or surgical.<\/jats:p><\/jats:sec>Results<\/jats:title>We identified 197 cases of HBV<\/jats:styled-content>\u2010related HCC<\/jats:styled-content>. The mean age was 57.9 \u00b1 12.9 years; 83% were male, and 55.3% and 35.3% were of A<\/jats:styled-content>sian and E<\/jats:styled-content>uropean descent respectively. Of 168 patient with available data, 146 (87%) had cirrhosis versus 22 (13%) without. Patients with cirrhosis tended to be older (median 60 vs 52 years, P<\/jats:styled-content><\/jats:italic> = 0.078). A<\/jats:styled-content>sian patients were more likely to have HCC<\/jats:styled-content> without cirrhosis than E<\/jats:styled-content>uropeans (17% vs 6%, P<\/jats:styled-content><\/jats:italic> = 0.04). There were no other differences identified between cirrhotic and non\u2010cirrhotic patients. Thirty\u2010four per cent of patients had tumours greater than 5\u2009cm at diagnosis, and 47% were diagnosed after presenting with symptoms. Twelve patients with HBV\u2010HCC<\/jats:styled-content> were outside current screening guidelines.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Most patients in M<\/jats:styled-content>elbourne with HBV<\/jats:styled-content>\u2010associated HCC<\/jats:styled-content> have cirrhosis. HCC<\/jats:styled-content> characteristics in non\u2010cirrhotic and cirrhotic patients were similar. The large number of patients detected through symptoms and with large tumours reinforces the need for vigilance in screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12068","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T11:16:12Z","timestamp":1356347772000},"page":"501-506","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epidemiology of hepatitis B<\/scp>\u2010associated hepatocellular carcinoma in V<\/scp>ictoria"],"prefix":"10.1111","volume":"43","author":[{"given":"M.","family":"Sinclair","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Melbourne Hospital Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Monash Medical Centre Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dev","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Monash Medical Centre Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gow","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Austin Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Philpott","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Austin Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Kronborg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Western Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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