{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T08:43:59Z","timestamp":1697445839583},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,9]],"date-time":"2013-06-09T00:00:00Z","timestamp":1370736000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin resistance (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) is a key factor in the development of hepatic steatosis and fibrosis in chronic hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus infection. Little is known about the impact of viral clearance on <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine the impact of viral clearance on <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010six patients treated according to standard clinical practice at an <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian teaching hospital between 2003 and 2007 were prospectively studied. Demographic, biochemical and histological data were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean pretreatment homeostatic model assessment\u2013<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content>) was similar in the sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> groups (2.7 \u00b1 0.5 and 2.8 \u00b1 0.4, respectively), and both values were consistent with significant <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. There was a significant improvement in <jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content> (from 3.0 \u00b1 1.0 to 2.2 \u00b1 0.5, <jats:italic>P<\/jats:italic> = 0.04) at the end of treatment in the <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> group only. This trended towards significance at 6 months post\u2010treatment. Multiple regression analysis found improvement in both gamma\u2010glutamyl transpeptidase and alanine aminotransferase predicted improvement in <jats:styled-content style=\"fixed-case\">HOMA\u2010IR<\/jats:styled-content> when controlled for other potential factors (<jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hepatitis <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> virus clearance is associated with improvement in <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. Although baseline hepatic fibrosis is a predictor of <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, changes in <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> appear to be independent of changes in liver fibrosis. Treatment\u2010related improvement in gamma\u2010glutamyl transpeptidase and alanine aminotransferase seen with improved <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> may be a possible marker of reduction of hepatic oxidative stress.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12136","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T10:22:05Z","timestamp":1363688525000},"page":"656-662","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sustained virological response following chronic hepatitis <scp>C<\/scp> treatment is associated with improvement in insulin resistance"],"prefix":"10.1111","volume":"43","author":[{"given":"C. H. Y.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal North Shore Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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