{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:42:37Z","timestamp":1769600557161,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hurg\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>trauss syndrome (<jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>) is a rare, idiopathic systemic vasculitis. There is emerging evidence of an association between the presence or absence of antineutrophil cytoplasmic antibodies (<jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>) and clinical phenotype. Thromboembolism is an increasingly recognised complication of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Given the paucity of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian data, the aim of this study was to examine the clinical and laboratory features of <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> in a single <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of all patients who fulfilled the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ollege of <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>heumatology classification criteria for <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> managed at the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartment of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>mmunology, <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>oyal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>delaide <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital between 2002 and 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen patients were included. All patients had asthma and most had upper airway involvement. Peripheral nerve, musculoskeletal, gastrointestinal and cutaneous involvement was common. Renal and cardiac involvement was uncommon in this series. Histological confirmation was obtained in 15 patients (78.9%). Ten patients (52.6%) were <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>+, and these were more likely to have musculoskeletal involvement, such as arthralgia or myalgia (odds ratio 57, <jats:italic>P =<\/jats:italic> 0.005). Thrombosis was a feature at diagnosis in six patients (31.6%); two of these recurred with relapse. Sixteen patients (84.2%) were followed up; five died, and mean survival was 8.9 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian study to focus on <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content>. Our results demonstrate similar presentation and prognosis of <jats:styled-content style=\"fixed-case\">CSS<\/jats:styled-content> to previous descriptions; however, we noted that musculoskeletal involvement was more common in <jats:styled-content style=\"fixed-case\">ANCA<\/jats:styled-content>+ patients. In our series, thrombosis was a significant complication and we suggest that thromboprophylaxis may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12173","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T11:07:18Z","timestamp":1366801638000},"page":"784-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical and laboratory characteristics of 19 patients with <scp>C<\/scp>hurg\u2013<scp>S<\/scp>trauss syndrome from a single <scp>S<\/scp>outh <scp>A<\/scp>ustralian centre"],"prefix":"10.1111","volume":"43","author":[{"given":"A. F.","family":"Whyte","sequence":"first","affiliation":[{"name":"Human Immunology SA Pathology\/IMVS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Royal Adelaide Hospital"},{"name":"AllergySA  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. N.","family":"Sinkar","sequence":"additional","affiliation":[{"name":"South Australian Institute of Ophthalmology Royal Adelaide Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E.","family":"Kette","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Royal Adelaide Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hissaria","sequence":"additional","affiliation":[{"name":"Human Immunology SA Pathology\/IMVS"},{"name":"Clinical Immunology and Allergy Royal Adelaide Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198403000-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21250"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-9-200511010-00006"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.058"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199601000-00003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3280119854"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32831de4e7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029609348647"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01672.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330806"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199901000-00003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37721"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.3.427"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.11.1286"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00359-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes155"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21704"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11454"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken035"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016112801784594"},{"key":"e_1_2_7_22_1","first-page":"456","article-title":"Caval thromboses and systemic diseases","volume":"137","author":"Fassin D","year":"1986","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.11.1181"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00691.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.088096"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23198"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T03:19:56Z","timestamp":1696216796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/imj.12173"],"URL":"https:\/\/doi.org\/10.1111\/imj.12173","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"2013-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}