{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:47:02Z","timestamp":1781311622888,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients treated for early prosthetic joint infection (<jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content>) with surgical debridement, prosthesis retention and biofilm\u2010active antibiotics, such as rifampicin or fluoroquinolones have a rate of successful infection eradication that is similar to patients treated with the traditional approach of prosthesis exchange. It is therefore important to consider other outcomes after <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content> treatment that may influence management decisions, such as function, quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) and treatment\u2010associated complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims:\u2002<\/jats:title><jats:p>To describe rates of successful treatment for patients with <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content> undergoing surgical debridement, prosthesis retention and biofilm\u2010active antibiotics and compare their functional outcomes, <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> and complication rates to patients without <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:\u2002<\/jats:title><jats:p>Nineteen patients treated for <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content> after hip arthroplasty with debridement, prosthesis retention and biofilm\u2010active antibiotics were matched to 76 controls who underwent hip arthroplasty with no infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:\u2002<\/jats:title><jats:p>Cumulative survival free from treatment failure at 2 years was 88% (95% confidence interval, 59\u201397%). <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content> cases had significant improvement from pre\u2010arthroplasty to 12\u2010months post\u2010arthroplasty in function according to Harris Hip Score and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content> according to the 12\u2010item Short Form Health Survey Physical Component Summary. There was no significant difference in the improvement between controls and cases. <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content> was not a risk factor for poor function or <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>. Medical complications occurred more frequently in cases (6\/19 (32%)) than controls (9\/76 (12%); <jats:italic>P =<\/jats:italic> 0.04), with this difference being accounted for by drug reactions. Surgical complications were the same in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content> with debridement, prosthesis retention and biofilm\u2010active antibiotics is successful, well tolerated and results in significant improvements in function and <jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>, which are similar to patients without <jats:styled-content style=\"fixed-case\">PJI<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12174","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T08:26:46Z","timestamp":1368088006000},"page":"810-815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["<scp>E<\/scp>arly prosthetic hip joint infection treated with debridement, prosthesis retention and biofilm\u2010active antibiotics: functional outcomes, quality of life and complications"],"prefix":"10.1111","volume":"43","author":[{"given":"C.","family":"Aboltins","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases St Vincent's Hospital"},{"name":"University of Melbourne Department of Medicine Northern Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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