{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T14:05:59Z","timestamp":1744639559359},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To identify the underlying heart disease and microbiological pathogen associated with infective endocarditis (<jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients in one university hospital over a 10\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 115 adult patients admitted to <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eking <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>irst <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital from 2002 to 2011 who were diagnosed with definite <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>. Statistical analysis was performed to analyse data on demographics, clinical and laboratory findings, as well as microbiological pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common underlying heart diseases for <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> were congenital heart disease (24.3%) followed by degenerative valvular disease (17.4%). Aortic (44.3%) and mitral (43.5%) valves were most frequently affected. The right\u2010sided <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> cases were all found in patients with congenital heart disease. The age of patients was younger in right\u2010sided cases than that in left\u2010sided ones (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.001). There was no difference in the mortality among groups with different underlying heart disease (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.841). Forty\u2010four (38.3%) patients were infected with <jats:italic>viridans<\/jats:italic> group <jats:italic>streptococci<\/jats:italic>. The isolation rate of staphylococci in right\u2010sided <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> was higher than that in the left\u2010sided <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content> group (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic> = 0.021). More than 85% of streptococci were susceptible to \u03b2\u2010lactams.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Congenital heart disease and degenerative valvular disease have overtaken rheumatic heart disease as the major underlying heart diseases associated with <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>. <jats:italic>Viridans<\/jats:italic> group <jats:italic>streptococci<\/jats:italic> are the most common microbial cause of <jats:styled-content style=\"fixed-case\">IE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12248","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T10:09:09Z","timestamp":1374487749000},"page":"1303-1309","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Underlying heart disease and microbiological spectrum of adult infective endocarditis in one <scp>C<\/scp>hinese university hospital: a 10\u2010year retrospective study"],"prefix":"10.1111","volume":"43","author":[{"given":"X. Z.","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Anti\u2010Infection Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anti\u2010Infection Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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