{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:45:44Z","timestamp":1761101144584},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T00:00:00Z","timestamp":1384473600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Voluntary donations of peripheral blood stem cells after administration of filgrastim (granulocyte\u2010colony stimulating factor, G\u2010CSF<\/jats:styled-content>) are undertaken throughout the world by healthy individuals, but the short\u2010, medium\u2010 and long\u2010term adverse events during and after donation are not fully understood.<\/jats:p><\/jats:sec>Aims<\/jats:title>We document the experience of donors of peripheral blood stem cells mobilised by G\u2010CSF<\/jats:styled-content> at A<\/jats:styled-content>ustralian B<\/jats:styled-content>one M<\/jats:styled-content>arrow D<\/jats:styled-content>onor R<\/jats:styled-content>egistry collection centres.<\/jats:p><\/jats:sec>Methods<\/jats:title>When the A<\/jats:styled-content>ustralian B<\/jats:styled-content>one M<\/jats:styled-content>arrow D<\/jats:styled-content>onor R<\/jats:styled-content>egistry commenced collecting mobilised peripheral blood stem cells, based on data used for registration of G\u2010CSF<\/jats:styled-content>, all adverse reactions in donors were documented prospectively to determine the rate and severity of events. A total of 512 consecutive first\u2010time donors assessed between J<\/jats:styled-content>uly 2001 and M<\/jats:styled-content>arch 2010 were included in this study.<\/jats:p><\/jats:sec>Results<\/jats:title>The median age at work\u2010up was 40 years and 71% of donors were male. A large proportion of donors (91%) experienced bone pain during administration of G\u2010CSF<\/jats:styled-content>, and in fewer numbers headache (61%) and fatigue (61%). Bone pain was associated with a body mass index of overweight\/obese (P =<\/jats:italic> 0.03). Headache (P =<\/jats:italic> 0.03), muscle pain (P =<\/jats:italic> 0.03) and fatigue (P =<\/jats:italic> 0.001) were all significantly associated with female sex. More than a quarter (28%) of donations involved a range of complications at collection.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The incidence of short\u2010 and medium\u2010term symptoms and events observed provide support for the information provided to unrelated donors at counselling. Follow up of the consequences of unrelated voluntary donation remains important to provide accurate and relevant information to prospective donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12282","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T08:41:09Z","timestamp":1378456869000},"page":"1183-1190","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Volunteer unrelated donor experience after administration of filgrastim and apheresis for the collection of haemopoietic stem cells: the A<\/scp>ustralian perspective"],"prefix":"10.1111","volume":"43","author":[{"given":"S. V.","family":"Gordon","sequence":"first","affiliation":[{"name":"ABMDR Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Nivison\u2010Smith","sequence":"additional","affiliation":[{"name":"ABMTRR Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Szer","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology and Bone Marrow Transplant Service Royal Melbourne Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Chapman","sequence":"additional","affiliation":[{"name":"ABMDR Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-175323"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13668"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702875"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2008.05.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.03.015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00384.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41020184.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01694.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3998"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240902849788"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703693"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.440"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1365-2141.2007.06524.x","article-title":"Long\u2010term safety of filgrastim (rhG\u2010CSF) administration","volume":"137","author":"Confer D","year":"2007","journal-title":"Br J Haematol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06529.x"},{"key":"e_1_2_7_16_1","first-page":"365","article-title":"Follow\u2010up of 12,559 unrelated donors of peripheral blood stem cells or bone marrow","volume":"116","author":"Schmidt AH","year":"2010","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2003.09.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348508"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-218651"},{"key":"e_1_2_7_20_1","first-page":"219","article-title":"Allogeneic peripheral blood stem cell collection as of 2008","volume":"38","author":"Rhodes B","year":"2008","journal-title":"Transfus Sci"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.04.012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703011"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.119"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12282","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:43:00Z","timestamp":1696167780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/imj.12282"],"URL":"https:\/\/doi.org\/10.1111\/imj.12282","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"2013-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}