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These include the use of non\u2010invasive methods to assess liver fibrosis, interleukin <jats:styled-content style=\"fixed-case\">28B<\/jats:styled-content> genotype testing to predict interferon responsiveness and the use of new anti\u2010viral regimens for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> genotype 1. Two new antiviral agents (boceprevir and telaprevir) have recently become available in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia. These protease inhibitors are used in combination with pegylated interferon and ribavirin as triple therapy for genotype 1 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. This combination increases sustained virological response from approximately 45\u201350% to 66\u201375% in treatment na\u00efve patients. However, these new regimens present novel challenges including complicated treatment algorithms based on virological response, numerous drug interactions and additional side effects especially in patients with advanced fibrosis. The protease inhibitors are the first of many antiviral drugs to become available to treat <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, heralding the arrival of new agents that will offer greater chances of cure with improved safety and tolerability compared with current therapies.<\/jats:p>","DOI":"10.1111\/imj.12304","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T08:36:56Z","timestamp":1386837416000},"page":"1265-1271","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advances in the management of hepatitis <scp>C<\/scp>"],"prefix":"10.1111","volume":"43","author":[{"given":"C.M.","family":"Croagh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lubel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Eastern Health  Melbourne Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"volume-title":"HIV, Viral Hepatitis and Sexually Transmissible Infections in Australia Annual Surveillance Report 2012","year":"2012","author":"The Kirby Institute","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","unstructured":"ANZLT Registry Report 2012.Australia and New Zealand Liver Transplant Registry Brisbane Qld Australia.LunchSV BaldersonGA eds. 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