{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:54:38Z","timestamp":1789844078669,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ejaculatory dysfunction is a common complaint and is often associated with a reduced quality of life for sufferer and partner. The spectrum of ejaculatory dysfunction extends from premature ejaculation (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) to delayed ejaculation (<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>) and anejaculation. Over the past 20\u201330 years, the<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>treatment paradigm, previously limited to behavioural psychotherapy, has expanded to include drug treatment. Multiple well\u2010controlled, evidence\u2010based studies have demonstrated the efficacy and safety of selective serotonin re\u2010uptake inhibitors in delaying ejaculation, confirming their role as first\u2010line agents for the treatment of lifelong and acquired<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>. More recently, there has been increased attention to the psychosocial consequences of<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>, its epidemiology, its aetiology and its pathophysiology by both clinicians and the pharmaceutical industry.<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>and anejaculation are probably the least common, least studied and least understood of the male sexual dysfunctions. However, their impact is significant as they may result in a lack of sexual fulfilment for both the man and his partner, an effect further compounded when procreation is among the couple's goals of sexual intercourse. The causes of<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>, anejaculation and anorgasmia are manifold. Numerous psychotherapeutic treatments are described for the management of delayed or anejaculation. Although some appear to be effective, none has been properly evaluated in large\u2010scale samples. Treatment of<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>or anejaculation with pharmacotherapy has met with limited success. No drugs have been approved by regulatory agencies for this purpose, and most drugs that have been identified for potential use have limited efficacy, impart significant side\u2010effects or are yet considered experimental in nature.<\/jats:p>","DOI":"10.1111\/imj.12344","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T09:42:29Z","timestamp":1392630149000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Management of ejaculatory dysfunction"],"prefix":"10.1111","volume":"44","author":[{"given":"C. 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