{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:31:01Z","timestamp":1711413061890},"reference-count":3,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Haemophagocytic lymphohistiocytosis (<jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>) is a rare but potentially fatal disease of children and adults. Cytokine dysfunction, uncontrolled accumulation of activated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cells and histiocytes, and the inability to terminate the immune response lead to the clinical manifestations of extreme inflammation and end\u2010organ damage. <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> is notoriously underreported because of its ability to mimic many other common diseases. Here, we outline two cases of <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>, one primary and the other secondary, to highlight some of the differences and to discuss therapeutic principles and emerging concepts.<\/jats:p>","DOI":"10.1111\/imj.12347","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T09:42:29Z","timestamp":1392630149000},"page":"198-201","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Two\u2010faced haemophagocytic lymphohistiocytosis: comparative review of two cases of adult haemophagocytic lymphohistiocytosis"],"prefix":"10.1111","volume":"44","author":[{"given":"E.","family":"Mayson","sequence":"first","affiliation":[{"name":"Haematology Department Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Saverimuttu","sequence":"additional","affiliation":[{"name":"Haematology Department Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Warburton","sequence":"additional","affiliation":[{"name":"Haematology Department Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1182\/asheducation-2011.1.178","article-title":"Approach to haemophagocytic syndromes","volume":"2011","author":"Weitzman S","year":"2001","journal-title":"Am Soc Hematol Educ Prog"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:30:35Z","timestamp":1696156235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":3,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/imj.12347"],"URL":"https:\/\/doi.org\/10.1111\/imj.12347","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"2013-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}