{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:29:26Z","timestamp":1756682966384},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T00:00:00Z","timestamp":1404691200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tuberculosis (<jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>) remains an important issue in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralia with more than 85% of active cases contributed by overseas\u2010born persons. Other risk groups include older <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralians who acquired <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in the past and indigenous people. Immune suppression is an emerging risk factor for <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>, particularly due to the expanding group of conditions for which potent immunosuppressive therapies is now used. Screening for latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> is recommended in many risk groups including recent contacts of those with transmissible <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>, those undergoing immune suppressive therapy, recently arrived refugees or migrants from high\u2010risk countries and indigenous people with high rates of <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> in the local community. Interferon\u2010gamma release assay (<jats:styled-content style=\"fixed-case\">IGRA<\/jats:styled-content>) has now been available for several years for the diagnosis of latent <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. It is now used in many clinical situations, and despite the rapid rate of new publications, there are still gaps in our knowledge. This paper reviews the current role of interferon\u2010gamma release assay in various situations, to determine its place in current practice and to explore where uncertainties exist.<\/jats:p>","DOI":"10.1111\/imj.12469","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T06:23:29Z","timestamp":1404714209000},"page":"624-632","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Interferon\u2010gamma release assays and the diagnosis of tuberculosis: have they found their place?"],"prefix":"10.1111","volume":"44","author":[{"given":"J.","family":"Darby","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases St Vincent's Hospital Melbourne The University of Melbourne  Melbourne Victoria Australia"},{"name":"Nossal Institute for Global Health, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Black","sequence":"additional","affiliation":[{"name":"Nossal Institute for Global Health, Melbourne School of Population and Global Health The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Buising","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St Vincent's Hospital Melbourne The University of Melbourne  Melbourne Victoria Australia"},{"name":"Victorian Infectious Diseases Service Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"82","article-title":"Tuberculosis notifications in Australia, 2008 and 2009","volume":"36","author":"Barry C","year":"2012","journal-title":"Commun Dis Intell"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Targeted tuberculin testing and treatment of latent tuberculosis infection","volume":"49","year":"2000","journal-title":"MMWR"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02489.x"},{"key":"e_1_2_6_5_1","first-page":"289","article-title":"The strategic plan for control of tuberculosis in Australia: 2011\u20132015","volume":"36","author":"National Tuberculosis Advisory Committee of Communicable Diseases","year":"2012","journal-title":"Commun Dis Intell"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21705"},{"key":"e_1_2_6_7_1","first-page":"289","article-title":"Position statement on interferon\u2010gamma release assays in the detection of latent tuberculosis. 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