{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:48:06Z","timestamp":1747288086294},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Higher Education, Poland","award":["PBmn103"],"award-info":[{"award-number":["PBmn103"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antibodies against monomeric <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein, which is a target antigen expressed both in kidney tubules and uveal cells, have been recently detected in patients with active tubulointerstitial nephritis and uveitis syndrome. We report the case of an 65\u2010year\u2010old woman with acute renal failure caused by biopsy\u2010proven tubulointerstitial nephritis and the onset of uveitis 21 months later. The expression of monomeric <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein in kidney oligobiopsy was confirmed by immunohistochemical staining using mouse monoclonal antibody against human monomeric <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein. The levels of antibodies against monomeric <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein were 117% of the reference during the flare and 22% during the remission of the disease. The difference in the levels of antibodies against monomeric <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein during flare and remission, and above all positive biopsy staining, supports their pathogenic role in this disease.<\/jats:p>","DOI":"10.1111\/imj.12501","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T07:52:54Z","timestamp":1406879574000},"page":"809-812","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pathogenic role of antibodies against monomeric <scp>C<\/scp>\u2010reactive protein in tubulointerstitial nephritis and uveitis syndrome"],"prefix":"10.1111","volume":"44","author":[{"given":"K.","family":"Jakuszko","sequence":"first","affiliation":[{"name":"Department and Clinic of Nephrology and Transplantation Medicine  Wroclaw 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