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Urgent and adequate thiamine replacement is necessary to avoid death or progression to\n                    <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\n                    orsakoff syndrome with largely irreversible brain damage.\n                    <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                    ernicke\n                    <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\n                    orsakoff syndrome refers to a condition where features of Wernicke encephalopathy are mixed with those of\n                    <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\n                    orsakoff syndrome. Although thiamine is the cornerstone of treatment of Wernicke encephalopathy, there are no universally accepted guidelines with regard to its optimal dose, mode of administration, frequency of administration or duration of treatment. Currently, different dose recommendations are being made. We present recommendations for the assessment and treatment of Wernicke encephalopathy based on literature review and our clinical experience.\n                  <\/jats:p>","DOI":"10.1111\/imj.12522","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T23:04:43Z","timestamp":1410217483000},"page":"911-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":154,"title":["Thiamine in the treatment of\n                    <scp>W<\/scp>\n                    ernicke encephalopathy in patients with alcohol use disorders"],"prefix":"10.1111","volume":"44","author":[{"given":"N.","family":"Latt","sequence":"first","affiliation":[{"name":"Northern Sydney Drug and Alcohol Service Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dore","sequence":"additional","affiliation":[{"name":"Northern Sydney Drug and Alcohol Service Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.4.341"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb139081.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.6.513"},{"key":"e_1_2_9_5_1","first-page":"21","article-title":"Wernicke encephalopathy: role of thiamine, nutrition issues in gastroenterology, series #75","volume":"23","author":"Thomson AD","year":"2009","journal-title":"Pract Gastroenterol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03153.x"},{"key":"e_1_2_9_7_1","volume-title":"The Wernicke Korsakoff Syndrome and Related Neurological Disorders Due to Alcoholism and Malnutrition","author":"Victor MV","year":"1989"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908173210706"},{"key":"e_1_2_9_9_1","unstructured":"CharnessME AminoffMJ WilterdinkJL.Overview of chronic neurological complications of alcohol 2013[cited 2013 Feb 19]. 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