{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:11:30Z","timestamp":1695618690336},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Measurement of the arterial partial pressure of oxygen (<jats:styled-content style=\"fixed-case\"><jats:roman>PaO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>) while breathing air is an informative investigation in patients with hypoxaemia due to chronic respiratory disease, but there are a lack of published data on the time needed for blood oxygen levels to equilibrate after cessation of supplemental oxygen (<jats:styled-content style=\"fixed-case\"><jats:roman>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>) in such patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the blood oxygen equilibration time after cessation of <jats:styled-content style=\"fixed-case\"><jats:roman>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> and thereby provide guidance on best timing of baseline arterial blood gas analysis in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medically stable subjects with chronic respiratory disease were administered <jats:styled-content style=\"fixed-case\"><jats:roman>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> at a constant concentration. Continuous pulse oximetry was recorded from before cessation of <jats:styled-content style=\"fixed-case\"><jats:roman>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> to beyond the point of oxygen saturation (<jats:styled-content style=\"fixed-case\"><jats:roman>SpO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>) equilibration. Data were fitted to an exponential decay model. Blood oxygen equilibration time was defined as the t90, the time taken for <jats:styled-content style=\"fixed-case\"><jats:roman>SpO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> to fall 90% of the difference between initial (on <jats:styled-content style=\"fixed-case\"><jats:roman>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>) and final (on air) values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010two (82) subjects with a mean age of 66 years were included. The largest diagnostic category was chronic obstructive pulmonary disease (37), followed by interstitial lung disease (15) and bronchiectasis (12). The median t90 was 6\u2009min 18\u2009s (interquartile range: 4\u2009min 32\u2009s\u201310\u2009min 30\u2009s). The 95th centile t90 value was 20\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the majority of patients with chronic respiratory disease, a time delay of 20\u2009min between cessation of supplemental <jats:styled-content style=\"fixed-case\"><jats:roman>O<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:roman>PaO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content> measurement allows confidence that the result is a true baseline value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12589","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T02:29:43Z","timestamp":1410920983000},"page":"26-32","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood oxygen equilibration time after cessation of supplemental oxygen in chronic respiratory disease"],"prefix":"10.1111","volume":"45","author":[{"given":"A. M. C.","family":"Stone","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K. H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Medical School University of Sydney  Sydney New South Wales Australia"},{"name":"The Woolcock Institute of Medical Research  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Medical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5305.627"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.67.3.259"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.67.3.256"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520762"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.103.2.554"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2009.06.009"},{"key":"e_1_2_6_8_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.04033.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2009.02101.x"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12589","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:34:07Z","timestamp":1695573247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/imj.12589"],"URL":"https:\/\/doi.org\/10.1111\/imj.12589","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"2014-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}