{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T20:53:40Z","timestamp":1763499220908},"reference-count":19,"publisher":"Wiley","issue":"12b","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article reports the findings of a survey developed to assess the current use of antifungal prophylaxis among haematology and infectious disease clinicians across Australia and<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew<jats:styled-content style=\"fixed-case\">Z<\/jats:styled-content>ealand, and their alignment with existing consensus guidelines for the use of antifungal agents in the haematology\/oncology setting (published 2008). Surveyed clinicians largely followed the current recommendations for prophylaxis in the setting of induction chemotherapy for acute myeloid leukaemia, as well as autologous and low\u2010risk allogeneic haemopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). In keeping with guideline recommendations, posaconazole was the agent used by most centres for high\u2010risk allogeneic<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. However, its routine continuation for 75\u2013100 days post\u2010transplantation without de\u2010escalation suggested use beyond those indications described in the 2008 guidelines, namely pre\u2010engraftment neutropenia and graft\u2010versus\u2010host disease. Variations in practice were observed in other settings, such as acute lymphoblastic leukaemia and myelodysplastic syndrome, reflecting the general lack of evidence for antifungal prophylaxis in these patient populations and changing perceptions of risk. With regard to the availability of testing in cases of suspected breakthrough<jats:styled-content style=\"fixed-case\">IFD<\/jats:styled-content>, 40% of centres did not have access to investigative bronchoscopy within 48\u2009h of referral, and results of<jats:italic>Aspergillus<\/jats:italic>galactomannan (<jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>), fungal polymerase chain reaction and therapeutic drug monitoring (<jats:styled-content style=\"fixed-case\">TDM<\/jats:styled-content>) were not available within 48\u2009h in 83%, 90% and 85% of centres respectively. The survey's findings will influence the recommendations provided in the updated 2014 consensus guidelines for the use of antifungal agents in the haematology\/oncology setting.<\/jats:p>","DOI":"10.1111\/imj.12594","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T15:20:12Z","timestamp":1418052012000},"page":"1277-1282","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Survey of antifungal prophylaxis and fungal diagnostic tests employed in malignant haematology and haemopoietic stem cell transplantation (<scp>HSCT<\/scp>) in<scp>A<\/scp>ustralia and<scp>N<\/scp>ew<scp>Z<\/scp>ealand"],"prefix":"10.1111","volume":"44","author":[{"given":"S. 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