{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:33:16Z","timestamp":1791369196498,"version":"4.3.1"},"reference-count":99,"publisher":"Wiley","issue":"12b","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a strong argument for the use of antifungal prophylaxis in high\u2010risk patients given the significant mortality associated with invasive fungal disease, the late identification of these infections, and the availability of safe and well\u2010tolerated prophylactic medications. Clinical decisions about which patients should receive prophylaxis and choice of antifungal agent should be guided by risk stratification, knowledge of local fungal epidemiology, the efficacy and tolerability profile of available agents, and estimates such as number needed to treat and number needed to harm. There have been substantial changes in practice since the 2008 guidelines were published. These include the availability of new medications and\/or formulations, and a focus on refining and simplifying patient risk stratification. Used in context, these guidelines aim to assist clinicians in providing optimal preventive care to this vulnerable patient demographic.<\/jats:p>","DOI":"10.1111\/imj.12595","type":"journal-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T15:20:12Z","timestamp":1418052012000},"page":"1283-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014"],"prefix":"10.1111","volume":"44","author":[{"given":"S.","family":"Fleming","sequence":"first","affiliation":[{"name":"Malignant Haematology and Stem Cell Transplantation Service Alfred Health  Prahran Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Yannakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology and Bone Marrow Transplant Service The Royal Melbourne Hospital  Parkville Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Infection Control Peter MacCallum Cancer Centre  East Melbourne Victoria"},{"name":"Department of Paediatric Infectious Diseases Monash Children's Hospital Monash Health  Clayton Victoria"},{"name":"Paediatric Integrated Cancer Service  Parkville Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Infection Management and Prevention Service The Royal Children's Hospital Brisbane Queensland Health  Herston Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Grigg","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Austin Health  Heidelberg Victoria"},{"name":"School of Medicine The University of Melbourne  Melbourne Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Royal Perth Hospital  Perth Western Australia"},{"name":"School of Medicine and Pharmacology (RPH Unit) University of Western Australia  Perth Western Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bajel","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology and Bone Marrow Transplant Service The Royal Melbourne Hospital  Parkville Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"van Hal","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Royal Prince Alfred Hospital  Camperdown New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services ICPMR \u2013 Pathology West  Westmead New South Wales"},{"name":"Department of Infectious Diseases Westmead Hospital  Westmead New South Wales"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Milliken","sequence":"additional","affiliation":[{"name":"Department of Haematology St Vincent's Hospital  Darlinghurst New South Wales"},{"name":"Faculties of Medicine and Pathology The University of NSW  Kensington New South Wales"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. O.","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Health and Monash University  Prahran Victoria"},{"name":"Department of Clinical Haematology Alfred Health  Prahran Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Tam","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Melbourne  Melbourne Victoria"},{"name":"Department of Haematology Peter MacCallum Cancer Centre  East Melbourne Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Szer","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology and Bone Marrow Transplant Service The Royal Melbourne Hospital  Parkville Victoria"},{"name":"School of Medicine The University of Melbourne  Melbourne Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Weinkove","sequence":"additional","affiliation":[{"name":"Wellington Blood and Cancer Centre Capital and Coast District Health Board  Wellington New Zealand"},{"name":"Vaccine Research Group Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Slavin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Infection Control Peter MacCallum Cancer Centre  East Melbourne Victoria"},{"name":"School of Medicine The University of Melbourne  Melbourne Victoria"},{"name":"Victorian Infectious Diseases Service The Doherty Institute for Infection and Immunity  Parkville Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-7-199304010-00003"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/651263"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq121"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068266"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.11.010"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70076-8"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.6.1545"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.051995"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01723.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02014.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2011.23.1.5"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04794.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.004"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.740561"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-345"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05789.x"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22909"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/591969"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704543"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12650"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.01.004"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/522189"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01609.x"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/422312"},{"key":"e_1_2_4_27_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1056\/NEJMoa061098","article-title":"Posaconazole or fluconazole for prophylaxis in severe graft\u2010versus\u2010host disease","volume":"25","author":"Ullmann A","year":"2007","journal-title":"N Engl J Med"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00802-12"},{"key":"e_1_2_4_29_1","unstructured":"Schering\u2010Plough.Noxafil (posaconazole) Australian Approved Product Information 2014."},{"key":"e_1_2_4_30_1","unstructured":"CornelyOA DuarteRF HaiderP ChandrasekarP HelfgottD LopezJet\u2009al.Phase 3 pharmacokinetics (PK) and safety study of posaconazole (POS) tablet in patients at risk for invasive fungal infection (Abstract). European Society of Clinical Microbiology and Infectious Diseases; Berlin;2013."},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-268151"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08838.x"},{"key":"e_1_2_4_33_1","article-title":"Is there still a place for itraconazole prophylaxis in high\u2010risk hematology patients?","author":"Hal SJ","year":"2014","journal-title":"Ann Hematol"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00155-13"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182577485"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.5144\/1658-3876.2010.167"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/586739"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0196-y"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr271"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-151"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01525-13"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.04.016"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir969"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05841-11"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-14"},{"key":"e_1_2_4_46_1","unstructured":"Janssen.Sporanox (itraconazole) Australian Approved Product Information;2013."},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0220-x"},{"key":"e_1_2_4_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02139-12"},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294330"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00958-12"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.08.007"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02158.x"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70017-8"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24847"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23415"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08072.x"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.2165\/11599810-000000000-00000"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181aa6eae"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000155861.38641.ca"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181a6dec0"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24107"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403188"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12063"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.1999.00496.x"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2012.01770.x"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010802106564"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702654"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12040"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.3851"},{"key":"e_1_2_4_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10610"},{"key":"e_1_2_4_71_1","volume-title":"NHMRC Levels of Evidence and Grades for Recommendations for Developers of Clinical Practice Guidelines","author":"National Health and Medical Research Council (NHMRC)","year":"2009"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.147"},{"key":"e_1_2_4_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-263"},{"key":"e_1_2_4_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00454-06"},{"key":"e_1_2_4_75_1","first-page":"103","article-title":"Voriconazole or itraconazole for prevention of invasive fungal infections after allogeneic hematopoietic stem cell transplantation (ALLOHCT) \u2013 focus on patient preference and long\u2010term tolerability","volume":"95","author":"Marks I","year":"2010","journal-title":"Haematologica"},{"key":"e_1_2_4_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182331bc7"},{"key":"e_1_2_4_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182a74233"},{"key":"e_1_2_4_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05761-11"},{"key":"e_1_2_4_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01540-12"},{"key":"e_1_2_4_80_1","first-page":"512","article-title":"Efficacy of different prophylactic antifungal regimens in bone marrow transplantation","volume":"80","author":"Annaloro C","year":"1995","journal-title":"Haematologica"},{"key":"e_1_2_4_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2644"},{"key":"e_1_2_4_82_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-9-200305060-00006"},{"key":"e_1_2_4_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05727.x"},{"key":"e_1_2_4_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0783-3"},{"key":"e_1_2_4_85_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1128\/AAC.42.2.404","article-title":"Repeated\u2010dose pharmacokinetics of an oral solution of itraconazole in infants and children","volume":"42","author":"Repentigny L","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_2_4_86_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00706.x"},{"key":"e_1_2_4_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21239"},{"key":"e_1_2_4_88_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2473063.x"},{"key":"e_1_2_4_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03483.x"},{"key":"e_1_2_4_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp196"},{"key":"e_1_2_4_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.10.010"},{"key":"e_1_2_4_92_1","first-page":"577","article-title":"Randomized double\u2010blind study of liposomal amphotericin B (Ambisome) prophylaxis of invasive fungal infections in bone marrow transplant recipients","volume":"12","author":"Tollemar J","year":"1993","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_4_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22140"},{"key":"e_1_2_4_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-014-0601-9"},{"key":"e_1_2_4_95_1","unstructured":"GriggAPersonal correspondence;2014."},{"key":"e_1_2_4_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt068"},{"key":"e_1_2_4_97_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.063420"},{"key":"e_1_2_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.09.014"},{"key":"e_1_2_4_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32834ab1f4"},{"key":"e_1_2_4_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.11.008"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12595","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:49:55Z","timestamp":1694616595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":99,"journal-issue":{"issue":"12b","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/imj.12595"],"URL":"https:\/\/doi.org\/10.1111\/imj.12595","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"2014-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}