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Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>spergillus<\/jats:italic> species remain the most prevalent cause of invasive mould infections, <jats:italic>Scedosporium<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>F<\/jats:italic><\/jats:styled-content><jats:italic>usarium<\/jats:italic> species and the Mucormycetes continue to place a significant burden on the immunocompromised host. Evidence also suggests that infections caused by rare and emerging pathogens are increasing within the setting of broad\u2010spectrum antifungal prophylaxis and improved survival times placing immunosuppressed patients at risk for longer. 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