{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:24:57Z","timestamp":1740126297908,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic cardiomyopathy (<jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>) is the most common monogenic cardiac condition, with a range of investigation and management options available. Recent research has recommended management within multidisciplinary\u2010dedicated <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the clinical impact of attendance at a specialised clinic on the management of <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of patients attending the <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> Clinic @ The Alfred during the first 2 years of operation was performed. Outcome measures comprised improvements in management of <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> as a result of attending the clinic including risk stratification and further investigations, medication changes, referral for implantable cardioverter\u2010defibrillators (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>) and septal reduction therapy, and screening of first\u2010degree relatives (<jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following specialised clinic attendance, there was an increase in patients investigated with 24\u2010h Holter monitoring by 39%, stress echocardiography by 21% and cardiac magnetic resonance imaging by 70%. Medications were optimised in 47% of patients. Six\u2009per\u2009cent of patients underwent <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> implantation and 13% underwent septal myectomy. Seventy new <jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content> were screened identifying 10 new cases of <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Attendance at our specialised <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content> clinic leads to facilitation of cardiac investigations, optimisation of medical therapy, streamlining of referrals for <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content> implantation and septal reduction therapy, and improved family screening. Referral to a specialised clinic offering comprehensive management should be considered for all patients with <jats:styled-content style=\"fixed-case\">HCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12646","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T07:23:48Z","timestamp":1416295428000},"page":"255-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical benefits of a specialised clinic for hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"45","author":[{"given":"A.","family":"Beale","sequence":"first","affiliation":[{"name":"HCM Clinic @ The Alfred Heart Centre Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Macciocca","sequence":"additional","affiliation":[{"name":"HCM Clinic @ The Alfred Heart Centre Alfred Hospital  Melbourne Victoria Australia"},{"name":"Victorian Clinical Genetics Services Murdoch Childrens Research Institute  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-077X","authenticated-orcid":false,"given":"A.","family":"Olaussen","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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H.","family":"Ellims","sequence":"additional","affiliation":[{"name":"HCM Clinic @ The Alfred Heart Centre Alfred Hospital  Melbourne Victoria Australia"},{"name":"Baker IDI Heart and Diabetes Research Institute  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60397-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00965.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00855-6"},{"key":"e_1_2_7_6_1","first-page":"179","article-title":"The natural (and unnatural) history of hypertrophic obstructive cardiomyopathy","volume":"35","author":"Shah PM","year":"1974","journal-title":"Circ Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.11.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.8.858"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.084"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.825"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007094"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2011.07.017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.11.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.03.055"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2011.07.013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181612cc7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.05.007"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.069"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs064"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.08.010"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12460"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00285.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12646","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:34:55Z","timestamp":1695569695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/imj.12646"],"URL":"https:\/\/doi.org\/10.1111\/imj.12646","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"type":"print","value":"1444-0903"},{"type":"electronic","value":"1445-5994"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2014-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}