{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:36:28Z","timestamp":1784946988899,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reported risk of depression in patients with hypomagnesaemia is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The objective of this meta\u2010analysis was to assess the association between depression and hypomagnesaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed using <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase and <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link> from inception through <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ctober 2014. Studies that reported odds ratios, relative risks or hazard ratios comparing the risk of depression in patients with hypomagnesaemia were included. Pooled risk ratios (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated using a random\u2010effect, generic inverse variance method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six observational studies (three cohort studies, two cross\u2010sectional studies and a case\u2013control study) with a total of 19\u2009137 patients were identified and included in the data analysis. The pooled <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> of depression in patients with hypomagnesaemia was 1.34 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.01\u20131.79, I<jats:sup>2<\/jats:sup> = 33%). The association between depression and hypomagnesaemia was marginally insignificant after the sensitivity analysis including only cohort and case\u2013control studies, with a pooled <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> of 1.38 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.92\u20132.07, I<jats:sup>2<\/jats:sup> = 24%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates a potential association between hypomagnesaemia and depression. Further studies assessing the benefits of treatment of hypomagnesaemia in patients with depression are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12682","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T20:05:08Z","timestamp":1428005108000},"page":"436-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Hypomagnesaemia linked to depression: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"45","author":[{"given":"W.","family":"Cheungpasitporn","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Thongprayoon","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Mao","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Srivali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ungprasert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Varothai","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sanguankeo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Bassett Medical Center  Cooperstown New York USA"},{"name":"Department of Preventive and Social Medicine Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kittanamongkolchai","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830512Y.0000000044"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-9684(15)31103-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70283-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4236\/nm.2010.12009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.151"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830512Y.0000000002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-009-8421-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.03.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670802534408"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119287"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcu195"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12343"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90201-Y"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.155572"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00017-Z"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2014"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2004.01.006"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.11.007"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12682","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:07:28Z","timestamp":1695571648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/imj.12682"],"URL":"https:\/\/doi.org\/10.1111\/imj.12682","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"2014-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}