{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:18:37Z","timestamp":1784380717660,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aminoglycoside clearance depends on kidney function, but the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>herapeutic <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uidelines for antibiotics (version 14, 2010) recommend initial dosing based on weight without consideration of kidney function. Other guidelines that modify dosing based on kidney function estimates often use the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ockroft\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ault equation, but the role of the estimated glomerular filtration rate equations for this purpose is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the performance of current guideline dosing in achieving target area\u2010under\u2010the\u2010curve and examine the relative precision of the estimated glomerular filtration rate equations compared with traditional <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ockroft\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ault creatinine clearance in predicting aminoglycoside clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed 496 aminoglycoside treatment episodes involving 1377 infusions in adult patients. Conformity with antibiotic guideline dosing was achieved if the discrepancy between prescribed and recommended dose was less than 15%. Aminoglycoside clearance was determined from linear regression using a one compartment model with the Aminoglycoside Levels and Daily Dose Indicator programme. We assessed the precision of the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ockroft\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ault, Modification of Diet in renal Disease Study and Chronic Kidney Disease\u2013Epidemiology Collaboration (<jats:styled-content style=\"fixed-case\">CKD\u2013EPI<\/jats:styled-content>) equations in predicting aminoglycoside clearance by correlation and linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conformity with guideline dosing was not associated with achieving target area\u2010under\u2010the\u2010curve. The <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content> estimated glomerular filtration rate adjusted for body surface area showed the highest correlation (gentamicin, r = 0.66; tobramycin, r = 0.82) and best predictive model for aminoglycoside clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current guideline dosing may be suboptimal for achieving target area\u2010under\u2010the\u2010curve. The <jats:styled-content style=\"fixed-case\">CKD\u2010EPI<\/jats:styled-content> equation adjusted for patient body surface area best predicts aminoglycoside clearance, and could be evaluated as a covariate in determining initial aminoglycoside dosing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12684","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T10:47:49Z","timestamp":1420714069000},"page":"319-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of aminoglycoside dosing and estimated glomerular filtration rate in determining gentamicin and tobramycin area under the curve and clearance"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-4724","authenticated-orcid":false,"given":"A. K. 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