{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:54:07Z","timestamp":1790628847051,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beta\u2010lactam antibiotic\u2010related liver enzyme derangement can limit treatment options for infective exacerbations in cystic fibrosis (<jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>) bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify risk factors for elevated liver function tests (<jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content> patients receiving parenteral antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients attending The Prince Charles Hospital (<jats:styled-content style=\"fixed-case\">TPCH<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>dult <jats:styled-content style=\"fixed-case\">CF C<\/jats:styled-content>entre in 2012 were identified using the <jats:styled-content style=\"fixed-case\">CF R<\/jats:styled-content>esearch <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase and <jats:styled-content style=\"fixed-case\">CF D<\/jats:styled-content>ata <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry. <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>iochemistry and haematology panels between 1 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2012 and 31 <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012 for each patient were retrieved from <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>ueensland <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>athology and private pathology providers. Patients with <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content> more than three times the upper limit of normal were identified. For each laboratory test, concurrently administered antibiotic(s) were analysed from <jats:styled-content style=\"fixed-case\">TPCH<\/jats:styled-content> pharmacy dispensing system for patients who received intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) antibiotic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Abnormal liver enzymes were evident in significantly more patients receiving <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> antibiotics than patients who did not (43% vs 18%, <jats:italic>P<\/jats:italic> &lt; 0.001). Pre\u2010existing <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>\u2010related liver disease and total <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> antibiotic treatment days were not associated with abnormal <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content>. Higher <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein and peripheral eosinophil counts were not more common in patients with abnormal <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content>. Male sex, poorer lung function and lower leucocyte counts were associated with abnormal <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content>; however, these variables only explained 4.2% of the variance in the multivariable logistic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elevated <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content> are common during <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> antibiotic treatment in <jats:styled-content style=\"fixed-case\">CF<\/jats:styled-content>. Although specific antibiotic exposure may contribute to abnormal <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content> in a minority of cases, our study demonstrates that antibiotic\u2010induced liver injury is largely idiosyncratic and unpredictable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12707","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T03:34:01Z","timestamp":1422934441000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Idiosyncratic reactions are the most common cause of abnormal liver function tests in patients with cystic fibrosis"],"prefix":"10.1111","volume":"45","author":[{"given":"T.","family":"Jong","sequence":"first","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Department of Pharmacy The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Geake","sequence":"additional","affiliation":[{"name":"Adult Cystic Fibrosis Centre The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yerkovich","sequence":"additional","affiliation":[{"name":"Queensland Lung Transplant Service The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine University of Queensland The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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