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Three patients had macro\u2010<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> type 1. One patient with fibromyalgia underwent several explorations to find a muscular pathology; another, who had elevated <jats:styled-content style=\"fixed-case\">CK\u2010MB<\/jats:styled-content> (muscle\u2013brain fraction) activity, was referred to a cardiologist, and statin therapy was erroneously discontinued in two patients. Two patients had macro\u2010<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> type 2: a man with a neuroendocrine carcinoma and a woman with rheumatoid arthritis. Diagnosis of type 1 obviates the need to carry out pointless and expensive investigations seeking a neuromuscular or cardiac pathology, and also, the unwarranted discontinuation of statin therapy. Type 2 must prompt investigations for a neoplasm.<\/jats:p>","DOI":"10.1111\/imj.12710","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T20:05:08Z","timestamp":1428005108000},"page":"457-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Macro\u2010creatine kinase: a neglected cause of elevated creatine kinase"],"prefix":"10.1111","volume":"45","author":[{"given":"F.","family":"Aljuani","sequence":"first","affiliation":[{"name":"Department of Rheumatology G. Montpied Hospital Clermont\u2010Ferrand University  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tournadre","sequence":"additional","affiliation":[{"name":"Department of Rheumatology G. 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