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Although limited in its positive predictive value for coeliac disease, the strong disease association with specific <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genes imparts exceptional negative predictive value to <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> typing, enabling a negative result to exclude coeliac disease confidently. In response to mounting evidence that the clinical use and interpretation of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> typing often deviates from best practice, this article outlines an evidence\u2010based approach to guide clinically appropriate use of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> typing, and establishes a reporting template for pathology providers to improve communication of results.<\/jats:p>","DOI":"10.1111\/imj.12716","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T20:05:08Z","timestamp":1428005108000},"page":"441-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an <scp>A<\/scp>ustralasian perspective"],"prefix":"10.1111","volume":"45","author":[{"given":"J. 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