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Men on <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> may be elderly and have comorbidities that are exacerbated by <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>, such as cardiovascular disease, diabetes, obesity, sedentary lifestyle and osteoporosis. Studies on managing the impacts of <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> have focused on men with non\u2010metastatic disease, where <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> is given for a limited duration. However, some men with advanced or metastatic prostate cancer will achieve long\u2010term survival with palliative <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> and therefore also risk morbidity from prolonged <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content>. Furthermore, <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> is continued during the use of other survival\u2010prolonging therapies for men with advanced disease, and there is a general trend to use <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> earlier in the disease course. As survival improves, management of the metabolic effects of <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> becomes important for maintaining both quality and quantity of life. This review will outline the current data, offer perspectives for management of <jats:styled-content style=\"fixed-case\">ADT<\/jats:styled-content> complications in men with advanced prostate cancer and discuss avenues for further research.<\/jats:p>","DOI":"10.1111\/imj.12731","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T04:13:20Z","timestamp":1425356000000},"page":"141-148","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["\u2018First, do no harm\u2019: managing the metabolic impacts of androgen deprivation in men with advanced prostate cancer"],"prefix":"10.1111","volume":"46","author":[{"given":"A. 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