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Treatment usually involves management of the underlying malignancy; however, steroids have shown a benefit in published case reports. Here, we describe a patient with profound thrombocytopenia secondary to metastatic <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>. It was refractory to steroid and intravenous immunoglobulin, but the platelet count improved markedly following initiation of everolimus. The possible explanation includes immunomodulation, tumour lysis or a combination of both effects. This is the first reported case of everolimus used in paraneoplastic thrombocytopenia from <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>. More studies are needed for further investigation of its potential use in secondary immune thrombocytopenia from <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> and perhaps other malignancies.<\/jats:p>","DOI":"10.1111\/imj.12779","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T04:36:20Z","timestamp":1433997380000},"page":"666-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Resolution of paraneoplastic immune thrombocytopenia following everolimus treatment for metastatic renal cell carcinoma"],"prefix":"10.1111","volume":"45","author":[{"given":"S.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Haematology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Oncology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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