{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:54:39Z","timestamp":1785873279926,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1039662"],"award-info":[{"award-number":["1039662"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Eosinophilic esophagitis (EoE<\/jats:styled-content>) is a newly recognised condition that is apparently increasing in prevalence, and the aetiology is poorly understood. The role of aeroallergens in EoE<\/jats:styled-content> is controversial, given the success of dietary therapy. Massive aeroallergen exposure leading to food bolus obstruction events (FBOE<\/jats:styled-content>) has been described, and the diagnosis of EoE<\/jats:styled-content> by esophageal biopsy noted to be more common in the pollen season according to previous case series.<\/jats:p><\/jats:sec>Aim<\/jats:title>To determine if a seasonal variation and a geographical variation occurred in EoE<\/jats:styled-content> presenting as FBOE<\/jats:styled-content> in adults, and to track the prevalence of FBOE<\/jats:styled-content> and EoE<\/jats:styled-content> over time.<\/jats:p><\/jats:sec>Method<\/jats:title>A retrospective case\u2013control study analysis was performed from J<\/jats:styled-content>anuary 2002 to J<\/jats:styled-content>anuary 2012 to identify all FBOE<\/jats:styled-content> in adults presenting to five tertiary hospitals in M<\/jats:styled-content>elbourne, A<\/jats:styled-content>ustralia. Endoscopy, histopathological reports, case notes and blood tests were examined, and postcodes recorded. Records of pollen counts were obtained. Cases were defined according to esophageal biopsy and grouped based on month of diagnosis. All other causes of FBOE<\/jats:styled-content> served as controls.<\/jats:p><\/jats:sec>Results<\/jats:title>One thousand, one hundred and thirty\u2010two FBOE<\/jats:styled-content> were identified. Biopsies were only performed in 278 of these cases, and 85 patients were found to have EoE<\/jats:styled-content> after biopsy. Patients with EoE<\/jats:styled-content> were younger (mean age 38 years, range 18\u201372) compared with those with alternative diagnosis (mean age 64.4 range 22\u201392), more likely to be male (M<\/jats:styled-content>\u2009:\u2009F<\/jats:styled-content> = 4:1 compared with 1.68:1 ) and had a higher eosinophil count in venous blood. Overall no seasonality was demonstrated in FBOE<\/jats:styled-content> secondary to any diagnosis, although the six cases of recurrent FBOE<\/jats:styled-content> secondary to EoE<\/jats:styled-content> mainly occurred in the grass pollen season in subsequent years. FBOE<\/jats:styled-content> cases were evenly distributed throughout metropolitan Melbourne irrespective of population density. EoE<\/jats:styled-content> as a percentage of FBOE<\/jats:styled-content> increased over time.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Seasonal aeroallergens may be important for a subgroup of patients with EoE<\/jats:styled-content> presenting as recurrent FBOE<\/jats:styled-content>. Esophageal biopsies are performed in a minority of patients, representing a significant departure from ideal management and contributing to recurrent unnecessary FBOE<\/jats:styled-content>. EoE<\/jats:styled-content> is an increasingly important cause of FBOE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.12790","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T07:24:41Z","timestamp":1428996281000},"page":"939-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis"],"prefix":"10.1111","volume":"45","author":[{"given":"H. L.","family":"Philpott","sequence":"first","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Gastroenterology Eastern Health Melbourne Victoria Australia"},{"name":"Department of Gastroenterology St Vincents Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nandurkar","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Gastroenterology Eastern Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Thien","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Gastroenterology Eastern Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincents Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincents Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Boyapati","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Austin Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Finch","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Royce","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University Melbourne Victoria Australia"},{"name":"Department of Gastroenterology The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.2.181"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e328347bb10"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.10"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.03.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07390.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2014.06.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04199.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.169"},{"key":"e_1_2_6_11_1","first-page":"205","article-title":"De\u2010novo onset of eosinophilic esophagitis after large volume allergen exposures","volume":"22","author":"Wolf WA","year":"2013","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000225590.08825.77"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.06.029"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2011.04.011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2007.09.009"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12790","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:14:32Z","timestamp":1695554072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/imj.12790"],"URL":"https:\/\/doi.org\/10.1111\/imj.12790","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"2015-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}