{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:23:13Z","timestamp":1784852593957,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastric antral vascular ectasia (<jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content>) is a rare but important cause of upper gastrointestinal bleeding. It is commonly associated with autoimmune conditions such as systemic sclerosis, and standard treatment involves both supportive measures, as well as endoscopic interventional therapies. While the current therapies are effective for most patients, a few patients develop severe and refractory bleeding. Herein we report two cases of refractory <jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content> in patients with diffuse scleroderma, which improved significantly after the administration of intravenous cyclophosphamide. One of these cases is, to our knowledge, the first reported case of cyclophosphamide being used specifically for the treatment of refractory <jats:styled-content style=\"fixed-case\">GAVE<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/imj.12883","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T02:58:40Z","timestamp":1443754720000},"page":"1077-1081","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intravenous cyclophosphamide as a therapeutic option for severe refractory gastric antral vascular ectasia in systemic sclerosis"],"prefix":"10.1111","volume":"45","author":[{"given":"D. A.","family":"Papachristos","sequence":"first","affiliation":[{"name":"Department of Rheumatology St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nikpour","sequence":"additional","affiliation":[{"name":"Department of Rheumatology St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hair","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Barwon Health  Geelong Victoria Australia"},{"name":"Department of Medicine Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Rheumatology St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(84)80080-3"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199210000-00019"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199210000-00019"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03739.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121087"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090600"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100124"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130386"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740801998754"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00088.x"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.08.038"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1391395"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.04.173"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.8.796"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081247"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.12883","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.12883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:06:34Z","timestamp":1695477994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.12883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/imj.12883"],"URL":"https:\/\/doi.org\/10.1111\/imj.12883","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"2015-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}