{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:24:02Z","timestamp":1791145442849,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,6]]},"abstract":"\n Background<\/jats:title>\n \n Methamphetamine abuse is a growing public health problem, and increasing numbers of patients are admitted with methamphetamine\u2010associated cardiomyopathy (\n MAC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n We sought to characterise the patterns of this disease and identify predictors of recovery.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively studied consecutive patients diagnosed with\n MAC<\/jats:styled-content>\n between January 2006 and July 2015.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified 20 patients (14 males, 6 females) with mean age 35\u2009\u00b1\u20099\u2009years. Most had very severe systolic dysfunction (mean left ventricular ejection fraction (LVEF) 19.7\u2009\u00b1\u200911.4%) at presentation with 14 requiring inotropes and 5 requiring mechanical support. The pattern of systolic dysfunction was global in 14 patients, while 6 patients had a \u2018reverse Takotsubo\u2019 (RT) pattern with severely hypokinetic basal\u2010mid segments and apical preservation. RT patients were predominantly female, had a short history of methamphetamine abuse and had higher cardiac enzyme levels. Patients with global dysfunction tended to have mid\u2010wall fibrosis on cardiac magnetic resonance imaging. On follow\u2010up transthoracic echocardiography, 6 out of 19 (32%) had normalisation of\n LVEF<\/jats:styled-content>\n (\n LVEF<\/jats:styled-content>\n \u2265 50%) within 6\u2009weeks. Smaller left ventricular and left atrial size, shorter duration of methamphetamine use and\n RT<\/jats:styled-content>\n pattern appeared to predict early recovery.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A subset of\n MAC<\/jats:styled-content>\n patients, particularly those with a\n RT<\/jats:styled-content>\n pattern and lesser ventricular dilatation have the potential for early recovery of ventricular function. By contrast, those with evidence of myocardial fibrosis and ventricular enlargement have limited scope for recovery.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.13050","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T02:18:36Z","timestamp":1456798716000},"page":"723-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Methamphetamine\u2010associated cardiomyopathy: patterns and predictors of recovery"],"prefix":"10.1111","volume":"46","author":[{"given":"A.","family":"Voskoboinik","sequence":"first","affiliation":[{"name":"Department of Cardiology The Alfred Hospital, Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Ihle","sequence":"additional","affiliation":[{"name":"Department of Intensive Care The Alfred Hospital, Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Alfred Hospital, Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Alfred Hospital, Melbourne Victoria Australia"},{"name":"Heart Failure Research Baker IDI Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"e_1_2_6_2_1","series-title":"Drug statistics series no. 28","volume-title":"National Drug Strategy Household Survey Detailed Report: 2013","author":"Australian Institute of Health and Welfare","year":"2014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.077"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22195"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.06.045"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.01.024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(79)90288-3"},{"key":"e_1_2_6_8_1","volume-title":"Cardiotoxicity Associated With Methamphetamine Use and Signs of Cardiovascular Pathology Among Methamphetamine Users","author":"Kaye S","year":"2005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq043"},{"key":"e_1_2_6_10_1","first-page":"251","article-title":"Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction","volume":"163","author":"Seiden LS","year":"1996","journal-title":"NIDA Res Monogr"},{"key":"e_1_2_6_11_1","first-page":"299","article-title":"Death in amphetamine users: causes and rates","volume":"112","author":"Kalant H","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004149900088"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(95)01765-B"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-199606000-00014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-46"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(15)60942-1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20367"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.12.078"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.01.009"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406761"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.12.010"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:44:14Z","timestamp":1695491054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/imj.13050"],"URL":"https:\/\/doi.org\/10.1111\/imj.13050","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2016-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}