{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:26:58Z","timestamp":1793179618415,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Nephrotic syndrome (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>) is a rare complication following allogeneic haemopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>), with limited current understanding of its pathogenesis. Here, we describe four cases of <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> following allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> diagnosed at our institutions to identify key clinical and pathological features. In addition, a <jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content> search was performed to identify existing reports that were pooled together with our cases for analysis. <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> occurred as a late complication following allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, with median onset 19.5\u2009months after transplant (range: 3.9\u201384\u2009months). The most common histopathology observed was membranous nephropathy; however, cases of minimal change disease have also been reported. There is a high incidence of prior extra\u2010renal graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GvHD<\/jats:styled-content>), with all four of our cases and 82% of published cases having prior <jats:styled-content style=\"fixed-case\">GvHD<\/jats:styled-content>. Glucocorticosteroids are the most common treatment, with variable degrees of response. Responses to immunosuppression with calcineurin inhibitors and rituximab have been described in steroid\u2010refractory cases.<\/jats:p>","DOI":"10.1111\/imj.13098","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T06:20:29Z","timestamp":1464934829000},"page":"737-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Nephrotic syndrome as a complication of chronic graft\u2010versus\u2010host disease after allogeneic haemopoietic stem cell transplantation"],"prefix":"10.1111","volume":"46","author":[{"given":"E.","family":"Wong","sequence":"first","affiliation":[{"name":"Clinical Haematology and Bone Marrow Transplant Unit Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lasica","sequence":"additional","affiliation":[{"name":"Clinical Haematology Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Z.","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Haematology and Bone Marrow Transplant Unit Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Clinical Haematology Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bajel","sequence":"additional","affiliation":[{"name":"Clinical Haematology and Bone Marrow Transplant Unit Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Clinical Haematology and Bone Marrow Transplant Unit Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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