{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:44:44Z","timestamp":1764783884705},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Goserelin, a form of medical ovarian suppression, is an effective treatment for pre\u2010menopausal women with breast cancer (<jats:styled-content style=\"fixed-case\">PMBC<\/jats:styled-content>). Meta\u2010analysis data showed that similar efficacy is achieved with medical ovarian suppression and non\u2010pharmacological ovarian suppression (<jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content>) \u2013 oophorectomy or ovarian irradiation. The acceptance rate of <jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content> remains low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study explored the reported toxicities of <jats:styled-content style=\"fixed-case\">PMBC<\/jats:styled-content> women and their preferred ovarian suppression method whilst on goserelin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A postal survey consisting of 22 study\u2010specific questions was sent to <jats:styled-content style=\"fixed-case\">PMBC<\/jats:styled-content> women who received goserelin at the Flinders Medical Centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen women were identified from the database; 12 versus 7 women received goserelin in the adjuvant versus metastatic setting respectively. Thirteen (68.4%) responded to the survey. Women in the adjuvant cohort were more likely to report toxicities. The most common were hot flushes (100% vs 50% <jats:italic>P<\/jats:italic> = 0.033), myalgia\/arthralgia (71.4% vs 16.7%, <jats:italic>P<\/jats:italic> = 0.048) and decreased libido (57\/1% vs 16.7%, <jats:italic>P<\/jats:italic> = 0.135). <jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content> was recalled to be offered to five (38.5%) women, with acceptance by one <jats:styled-content style=\"fixed-case\">BRCA2<\/jats:styled-content> carrier. <jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content> was declined initially due to fear of procedure, surgical\/anaesthetic risk, invasiveness and planned future pregnancies. If given the option, upfront oophorectomy was indicated in seven (53.8%) women due to inconveniences with monthly goserelin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Half of <jats:styled-content style=\"fixed-case\">PMBC<\/jats:styled-content> women indicated a preference to <jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content>, but only a minority recollected <jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content> being discussed. Inconvenience with monthly goserelin is the main driver toward a preference of favouring <jats:styled-content style=\"fixed-case\">NPOS<\/jats:styled-content>. Clarification from larger trials that research patients\u2019 decision process and preferences regarding ovarian suppression is needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13169","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T05:43:40Z","timestamp":1467956620000},"page":"1153-1159","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Goserelin toxicities and preferences for ovarian suppression method in pre\u2010menopausal women with breast cancer"],"prefix":"10.1111","volume":"46","author":[{"given":"A. H.\u2010C.","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kichenadasse","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Flinders Centre for Innovation in Cancer Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vatandoust","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Flinders Centre for Innovation in Cancer Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Flinders Centre for Innovation in Cancer Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Karapetis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Flinders Centre for Innovation in Cancer Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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