{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:34:49Z","timestamp":1792020889423,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,10]]},"abstract":"\n Background<\/jats:title>\n \n Viral causes of acute exacerbations of chronic obstructive pulmonary disease (\n AECOPD<\/jats:styled-content>\n ) are well recognised but only recently have rapid tests become available.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n To identify respiratory viruses in the general population and those associated with hospitalisation in\n AECOPD<\/jats:styled-content>\n using polymerase chain reaction (\n PCR<\/jats:styled-content>\n ) on nasopharyngeal aspirate (\n NPA<\/jats:styled-content>\n ), and the relationship between symptoms, viral detection and inflammatory markers.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A review of viruses detected in the general population in a health district between August 2014 and July 2015, using multiplex\n PCR<\/jats:styled-content>\n for viruses from\n NPA<\/jats:styled-content>\n samples. In addition, a single hospital, retrospective audit of patients admitted with suspected\n AECOPD<\/jats:styled-content>\n was conducted.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 8811\n NPA<\/jats:styled-content>\n tested, 5599 (64%) were positive for at least one virus and 2069 of these were obtained from adults. In adults, the most common viruses identified were Influenza A (31%), Rhinovirus (27%) and respiratory syncytial virus A\/B (10%). Most patients with\n AECOPD<\/jats:styled-content>\n (102 of 153) had\n NPA<\/jats:styled-content>\n sent for viral\n PCR<\/jats:styled-content>\n testing and 59 (58%) were positive. The most common viruses identified were Influenza A (31%), Rhinovirus (24%) and respiratory syncytial virus A\/B (17%) with co\u2010infecting bacteria cultured in 22 sputum samples. Patients with influenza\u2010like symptoms were more likely to have a positive viral\n PCR<\/jats:styled-content>\n than those without symptoms (\n P<\/jats:italic>\n < 0.004). The median C\u2010reactive protein on admission was lower in the virus\u2010infected than uninfected\n AECOPD<\/jats:styled-content>\n (28 vs 60 mg\/L,\n P<\/jats:italic>\n < 0.026).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The spectrum of viruses detected in patients with\n AECOPD<\/jats:styled-content>\n is similar to that of the general population. Viruses are more likely to be identified in patients with\n AECOPD<\/jats:styled-content>\n who present with influenza\u2010like symptoms and a low C\u2010reactive protein.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/imj.13213","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T03:06:00Z","timestamp":1470971160000},"page":"1160-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Viruses are frequently present as the infecting agent in acute exacerbations of chronic obstructive pulmonary disease in patients presenting to hospital"],"prefix":"10.1111","volume":"46","author":[{"given":"E.","family":"Biancardi","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Prince of Wales Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fennell","sequence":"additional","affiliation":[{"name":"Serology and Virology Division (SAViD) SEALS Microbiology Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"School of Medical Sciences and School of Biotechnology and Biomolecular Sciences The University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Rawlinson","sequence":"additional","affiliation":[{"name":"Serology and Virology Division (SAViD) SEALS Microbiology Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"School of Medical Sciences and School of Biotechnology and Biomolecular Sciences The University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Prince of Wales Hospital Sydney New South Wales Australia"},{"name":"Prince of Wales Clinical School and Inflammation Infection Research, School of Medical Sciences University of New South Wales Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2927"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.9.2105011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.1.37"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9901004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9911019"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0530"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092214"},{"key":"e_1_2_6_9_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. [cited 2016 Sep 10] Available from URL:http:\/\/goldcopd.org\/gold-spirometry-guide\/"},{"key":"e_1_2_6_10_1","first-page":"361","article-title":"Flutracking weekly online community survey of influenza\u2010like illness: 2013 and 2014","volume":"39","author":"Dalton CB","year":"2015","journal-title":"Commun Dis Intell Q Rep"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041822"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.01.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.09.020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.317"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T16:54:43Z","timestamp":1696265683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/imj.13213"],"URL":"https:\/\/doi.org\/10.1111\/imj.13213","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726652288.793537653","asserted-by":"object"}]},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"2016-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}