{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:09:54Z","timestamp":1793912994305,"version":"4.8.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients frequently report antibiotic allergies; however, only 10% of labelled patients have a true allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the documentation of antibiotic \u2018allergy\u2019 labels (<jats:styled-content style=\"fixed-case\">AAL<\/jats:styled-content>) and the effect of labelling on clinical outcomes, in a West Australian adult tertiary hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cross\u2010sectional analysis of patients captured in the 2013 and 2014 National Antimicrobial Prescribing Surveys was carried out. Data were collected on documented antibiotic adverse drug reactions, antibiotic cost, prescribing appropriateness, prevalence of multi\u2010drug resistant organisms, length of stay, intensive care admission and readmissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 687 patients surveyed, 278 (40%) were aged 70 or above, 365 (53%) were male and 279 (41%) were prescribed antibiotics. <jats:styled-content style=\"fixed-case\">AAL<\/jats:styled-content> were recorded in 122 (18%) patients and the majority were penicillin labels (<jats:italic>n<\/jats:italic>\u2009=\u200987; 71%). Details of <jats:styled-content style=\"fixed-case\">AAL<\/jats:styled-content> were documented for 80 of 141 (57%) individual allergy labels, with 61 describing allergic symptoms. Patients with beta\u2010lactam allergy labels received fewer penicillins (<jats:italic>P<\/jats:italic>\u2009=\u20090.0002) and more aminoglycosides (<jats:italic>P<\/jats:italic>\u2009=\u20090.043) and metronidazole (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) than patients without beta\u2010lactam labels. Five patients received an antibiotic that was contraindicated according to their allergy status. Patients with <jats:styled-content style=\"fixed-case\">AAL<\/jats:styled-content> had significantly more hospital readmissions within 4 weeks (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and 6 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.025) of discharge, compared with unlabelled patients. The majority (81%) of readmitted labelled patients had major infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">AAL<\/jats:styled-content> are common, but poorly documented in hospital records. Patients with <jats:styled-content style=\"fixed-case\">AAL<\/jats:styled-content> are significantly more likely to require alternative antibiotics and hospital readmissions. There may be a role for antibiotic allergy delabelling to mitigate the clinical and economic burdens for patients with invalid allergy labels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13223","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T09:02:46Z","timestamp":1471424566000},"page":"1276-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["The revolving door: antibiotic allergy labelling in a tertiary care centre"],"prefix":"10.1111","volume":"46","author":[{"given":"B.","family":"Knezevic","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Sprigg","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Seet","sequence":"additional","affiliation":[{"name":"Department of Research Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Trevenen","sequence":"additional","affiliation":[{"name":"Department of Research Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"Centre for Applied Statistics University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Trubiano","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Immunology Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Jeelall","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology Harry Perkins Institute of Medical Research  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vale","sequence":"additional","affiliation":[{"name":"Drug Allergy Working Party Australasian Society of Clinical Immunology and Allergy  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Princess Margaret Hospital  Perth Western Australia Australia"},{"name":"Pathwest Laboratory Queen Elizabeth II Campus  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"McLean\u2010Tooke","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Royal Perth Hospital  Perth Western Australia Australia"},{"name":"Pathwest Laboratory Queen Elizabeth II Campus  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Royal Perth Hospital  Perth Western Australia Australia"},{"name":"Pathwest Laboratory Queen Elizabeth II Campus  Perth Western Australia Australia"},{"name":"Department of Clinical Immunology Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"Institute for Immunology and Infectious Diseases Murdoch University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2819"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2498"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S54559"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.11.1348"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.11.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0476-y"},{"key":"e_1_2_6_8_1","unstructured":"South Australian Department for Health and Ageing Branch of Infection Control Service Communicable Disease Control. 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