{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:18:52Z","timestamp":1767903532041,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001775","name":"University of Technology Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite\u2010related symptoms from advanced cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional anonymous survey was administered from July to December 2015 online and in eight adult outpatient palliative care and\/or cancer services. Respondents were eligible if they were \u226518\u2009years, had advanced cancer and poor appetite\/taste problems\/weight loss and might consider participating in a medicinal cannabis trial. Survey items focused on medicinal rather than recreational cannabis use and did not specify botanical or pharmaceutical products. Items asked about previous medicinal cannabis use and preferences for delivery route and invited comments and concerns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 204 survey respondents, of whom 26 (13%) reported prior medicinal cannabis use. Tablets\/capsules were the preferred delivery mode (<jats:italic>n<\/jats:italic>\u2009=\u2009144, 71%), followed by mouth spray (<jats:italic>n<\/jats:italic>\u2009=\u200984, 42%) and vaporiser (<jats:italic>n<\/jats:italic>\u2009=\u200983, 41%). Explanations for preferences (<jats:italic>n<\/jats:italic>\u2009=\u2009134) most commonly cited convenience (<jats:italic>n<\/jats:italic>\u2009=\u200966; 49%). A total of 82% (<jats:italic>n<\/jats:italic>\u2009=\u2009168) of respondents indicated that they had no trial\u2010related concerns, but a small number volunteered concerns about adverse effects (<jats:italic>n<\/jats:italic>\u2009=\u200914) or wanted more information\/advice (<jats:italic>n<\/jats:italic>\u2009=\u20098). Six respondents volunteered a belief that cannabis might cure cancer, while two wanted assurance of efficacy before participating in a trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Justification of modes other than tablets\/capsules and variable understanding about cannabis and trials will need addressing in trial\u2010related information to optimise recruitment and ensure that consent is properly informed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13224","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T08:08:42Z","timestamp":1471421322000},"page":"1269-1275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Clinical trials of medicinal cannabis for appetite\u2010related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation"],"prefix":"10.1111","volume":"46","author":[{"given":"T.","family":"Luckett","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular and Chronic Care, Faculty of Health University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Chronic Care, Faculty of Health University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Lintzeris","sequence":"additional","affiliation":[{"name":"Discipline of Addiction Medicine, Central Clinical School Sydney Medical School  Sydney New South Wales Australia"},{"name":"Drug and Alcohol Services South East Sydney Local Health District, NSW Health  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Allsop","sequence":"additional","affiliation":[{"name":"School of Psychology The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Palliative Care Concord Repatriation General Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Solowij","sequence":"additional","affiliation":[{"name":"School of Psychology University of Wollongong  Wollongong New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lam","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Chronic Care, Faculty of Health University of Technology Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Palliative Care, Liverpool Cancer Therapy Centre Liverpool Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"McCaffrey","sequence":"additional","affiliation":[{"name":"Palliative and Supportive Services Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Currow","sequence":"additional","affiliation":[{"name":"Palliative and Supportive Services Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Chye","sequence":"additional","affiliation":[{"name":"Sacred Heart Supportive and Palliative Care St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Palliative Care, Greenwich Hospital HammondCare  Sydney New South Wales Australia"},{"name":"Northern Clinical School, Sydney Medical School HammondCare  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"McGregor","sequence":"additional","affiliation":[{"name":"Department of Psychopharmacology, Faculty of Science The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Agar","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular and Chronic Care, Faculty of Health University of Technology Sydney  Sydney New South Wales Australia"},{"name":"The Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"},{"name":"South Western Sydney Clinical School University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.01573"},{"key":"e_1_2_7_3_1","unstructured":"Media release by the Minister for Health. Historic Medicinal Cannabis Legislation Passes Parliament. 2016 Feb 24 [cited 2016 Mar 1]. Available from URL:http:\/\/www.health.gov.au\/internet\/ministers\/publishing.nsf\/Content\/health\u2010mediarel\u2010yr2016\u2010ley013.htm"},{"key":"e_1_2_7_4_1","volume-title":"2010 national drug strategy household survey report","author":"Australian Institute of Health and Welfare","year":"2011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6358"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112901"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057154"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100002584"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3959(02)00400-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/108729104323038892"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7517-2-18"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2005.09.006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018440"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.05.027"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2010.537732"},{"key":"e_1_2_7_16_1","unstructured":"Australian Government Department of Health Therapeutic Goods Administration. Good manufacturing practice \u2013 an overview [cited 2016 Jun 3]. Available from URL:https:\/\/www.tga.gov.au\/good\u2010manufacturing\u2010practice\u2010overview"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.2002.tb05998.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.952715"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.12.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq727"},{"key":"e_1_2_7_21_1","unstructured":"New South Wales Government. Terminal illness cannabis scheme [cited 2016 Feb 22]. Available from URL:http:\/\/www.nsw.gov.au\/tics"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.10.009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.12.020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909112454215"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9566.2012.01476.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/002204260303300204"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7517-9-12"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.7.1314"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199702000-00001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-016-9798-4"},{"key":"e_1_2_7_31_1","volume-title":"Australian cancer incidence and mortality (ACIM) books: all cancers combined","author":"Australian Institute of Health and Welfare","year":"2016"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:15:26Z","timestamp":1696169726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/imj.13224"],"URL":"https:\/\/doi.org\/10.1111\/imj.13224","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"2016-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}