{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:53:46Z","timestamp":1776995626002,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"China National Support Plan","award":["2011BAI10B00"],"award-info":[{"award-number":["2011BAI10B00"]}]},{"name":"Shanghai Key Laboratory and Blood Purification, Shanghai Science and Technology Commission Program","award":["14DZ2260200"],"award-info":[{"award-number":["14DZ2260200"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Glomerular M\u2010type phospholipase <jats:styled-content style=\"fixed-case\">A<jats:sub>2<\/jats:sub>\n<\/jats:styled-content> receptor (<jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content>) is important for diagnosing idiopathic membranous nephropathy (<jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content>). The relation between glomerular <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> expression and response to treatment remains to be explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We conducted the study to explore the positive rate and clinical significance of glomerular M\u2010type <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 122 <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> patients receiving neither glucocorticoid nor immunosuppressant therapy prior to renal biopsies was included and followed for more than 1\u2009year. The control group comprised 30 patients with secondary membranous nephropathy and 100 patients with non\u2010membranous forms of nephropathy. <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> level and <jats:styled-content style=\"fixed-case\">IgG<\/jats:styled-content> subclasses in glomeruli were detected. The primary end\u2010point was the reduction of proteinuria to less than 50% of baseline value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 82.0% of patients with <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> had positive glomerular <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> deposits, compared with 16.7% in the secondary membranous nephropathy group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Additionally, <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content>\u2010positive expression combined with <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content>\u2009\u2265\u20092+ was found in 94.3% <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> patients, compared with 40.0% in secondary membranous nephropathy patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Among <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> patients, the remission rate of proteinuria after either glucocorticoid or glucocorticoid combined immunosuppressant therapy for at least 6\u2009months was 83.9% in the <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content>\u2010positive group compared with 54.5% in the negative group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The positive rate of glomerular <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> was more prevalent in <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> patients. Both <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IgG4<\/jats:styled-content> glomerular deposits may help in discriminating between idiopathic and secondary membranous nephropathy. <jats:styled-content style=\"fixed-case\">IMN<\/jats:styled-content> patients with positive <jats:styled-content style=\"fixed-case\">PLA<jats:sub>2<\/jats:sub>R<\/jats:styled-content> expression probably have a more beneficial response to glucocorticoid and\/or immunosuppressant therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13233","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T07:52:42Z","timestamp":1472025162000},"page":"1318-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Detection and clinical significance of glomerular M\u2010type phospholipase <scp>A<sub>2<\/sub><\/scp> receptor in patients with idiopathic membranous nephropathy"],"prefix":"10.1111","volume":"46","author":[{"given":"H.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"},{"name":"Shanghai Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"},{"name":"Shanghai Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"},{"name":"Shanghai Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"},{"name":"Shanghai Key Laboratory of Kidney and Blood Purification  Shanghai 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