{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:06:45Z","timestamp":1769814405930,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Bone Marrow Cancer Research Trust"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic lymphocytic leukaemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) is associated with an increased incidence and aggressiveness of skin cancers, particularly cutaneous squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>), but little is known about <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> incidence in Australasian <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this retrospective study, we analysed the incidence of <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> in patients seen at a tertiary hospital in New Zealand (<jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed the clinical history and histology data of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients (<jats:italic>n<\/jats:italic> = 371) who presented to the Haematology Department, Christchurch Hospital, <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content> during the period 1996\u20132015. Baseline characteristics, incidence of second cancers, treatment details and overall survival were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During follow\u2010up (median = 11.8 years), 221 second cancers were recorded in 88 patients. Of these cancers, 185 were <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>, removed from 61 patients. In 56% of these patients, &gt;1 <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> was removed, and the majority of <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> occurred following the treatment for <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>. The cumulative incidence of a first <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> was 11% at 5 years, whereas the cumulative incidence of a subsequent <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> was 88% at 5 years. The incidence of <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> in male patients was threefold higher than that reported for the general <jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content> population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">NZ CLL<\/jats:styled-content> patients have a high incidence of <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> relative to the levels observed in the general population, which are themselves among the highest in the world. The careful monitoring of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients is warranted, particularly those who have a progressive disease or have had a first <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> removed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13261","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T15:12:46Z","timestamp":1474729966000},"page":"1414-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence of cutaneous squamous cell carcinoma in a New Zealand population of chronic lymphocytic leukaemia patients"],"prefix":"10.1111","volume":"46","author":[{"given":"B. D.","family":"Hock","sequence":"first","affiliation":[{"name":"Haematology Research Group Christchurch Hospital  Christchurch New Zealand"},{"name":"Department of Pathology University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. D.","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"Haematology Research Group Christchurch Hospital  Christchurch New Zealand"},{"name":"Department of Pathology University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Biostatistics and Computational Biology Unit University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Simcock","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Christchurch Hospital  Christchurch New Zealand"},{"name":"Department of Surgery University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Otago  Christchurch New Zealand"},{"name":"Haematology Department Christchurch Hospital  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.1112"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12564"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190310001612939"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.18.1422"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1979"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22672"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.028"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw072"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.313"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.381"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5398"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6993.1491"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.642"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.9605"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.4449"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6249"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.055"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24586"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100134668"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12208"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04976.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp482"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2456"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(96)00075-X"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970415)16:7<791::AID-SIM500>3.0.CO;2-#"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2010.05583.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00086.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2013.000921"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13261","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:06:32Z","timestamp":1695553592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/imj.13261"],"URL":"https:\/\/doi.org\/10.1111\/imj.13261","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"2016-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}