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The symptoms of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> are protean, often follow an asymptomatic phase and may include complications related to the paraneoplastic effects of <jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> paraprotein. The revised 2016 World Health Organization classification includes the <jats:styled-content style=\"fixed-case\">MYD88 L265P<\/jats:styled-content> mutation, which is seen in &gt;90% of cases, within the diagnostic criteria for <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>. While treatment of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> has often been considered together with other indolent B cell lymphomas, there are unique aspects of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> management that require specific care. These include the unreliability of <jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> and paraprotein measurements in monitoring patients prior to and after treatment, the lack of correlation between disease burden and symptoms and rituximab\u2010induced <jats:styled-content style=\"fixed-case\">IgM<\/jats:styled-content> flare. Moreover, while bendamustine and rituximab has recently been approved for reimbursed frontline use in <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> in Australia, other regimens, including ibrutinib\u2010 and bortezomib\u2010based treatments, are not funded, requiring tailoring of treatment to the regional regulatory environment. The Medical and Scientific Advisory Group of the Myeloma Foundation Australia has therefore developed clinical practice guidelines with specific recommendations for the work\u2010up and therapy of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> to assist Australian clinicians in the management of this disease.<\/jats:p>","DOI":"10.1111\/imj.13311","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T05:52:47Z","timestamp":1484286767000},"page":"35-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment of patients with Waldenstr\u00f6m macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group"],"prefix":"10.1111","volume":"47","author":[{"given":"Dipti","family":"Talaulikar","sequence":"first","affiliation":[{"name":"Department of Haematology Canberra Hospital  Canberra Australian 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