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Our aim was to review the current evidence for screening, diagnosis and treatment in hepatitis A to E. Evidence for this review was sourced from international and Australian guidelines and high\u2010quality clinical trials. <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> was searched using structured key word strategy and retrieved articles were reviewed methodically to inform a brief and up\u2010to\u2010date synopsis of hepatitis A to E. We share some of the recent developments in viral hepatitis, specifically the new therapies for hepatitis C. Direct\u2010acting antiviral therapies are safe, well\u2010tolerated and effective. Subsidies allow access for all Australians with most strains of hepatitis C. We outline evidence underpinning efficacy and safety of treatment for hepatitis B, while clarifying some of the nuances in the setting of pregnancy and immunosuppression. We provide a simplified concept to facilitate understanding of the five phases of hepatitis B; practical for real\u2010world setting. Hepatitis A to E is a broad topic, not all aspects of these viruses can be covered in this short review. 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