{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:06Z","timestamp":1740126306115,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>First\u2010line <jats:italic>Helicobacter pylori<\/jats:italic> eradication failure is a common and challenging problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of salvage levofloxacin\u2010based triple therapy in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective patients referred after prior treatment failure(s) were prescribed esomeprazole 40 mg, amoxicillin 1 g and levofloxacin 500 mg each twice daily for 10 days. All patients received detailed written and verbal adherence support. Outcome assessment was by <jats:styled-content style=\"fixed-case\">\n<jats:sup>13<\/jats:sup>C<\/jats:styled-content>\u2010urea breath test and\/or histology and urease test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 150 consecutive, evaluable patients (66% female, mean age 54 \u00b1 14 years; six smokers), the main indications for treatment were peptic ulcer disease (17%), increased gastric cancer risk (20%), symptoms (35%) and other risk reduction (28%). The median number of previous treatments was 2 (range 1\u20137). Eradication of <jats:italic>H. pylori<\/jats:italic> was achieved in 90% (intention to treat (<jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>)) and 91% (per\u2010protocol (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>)) of patients. The eradication rate did not differ according to the type or number of prior treatments: 93% when \u22642 (<jats:italic>n<\/jats:italic> = 107) compared with 84% after three or more prior treatments (<jats:italic>n<\/jats:italic> = 43; <jats:italic>P<\/jats:italic> = 0.13) or with age, ethnicity or indication for treatment but it was higher in females (<jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content> 94 vs 82%, <jats:italic>P<\/jats:italic> = 0.04). Adherence was excellent (95%). No serious adverse effects were observed; mild adverse effects were reported in 11%. No primary levofloxacin resistance was observed in 20 concurrent cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy and safety of this levofloxacin\u2010based triple therapy suggests it should be used as a salvage regimen in this region. Randomised comparative trials are unlikely to be done but these data compare favourably with local data for other salvage therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13432","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T08:18:46Z","timestamp":1490602726000},"page":"761-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A prospective evaluation of levofloxacin\u2010based triple therapy for refractory <i>Helicobacter pylori<\/i> infection in Australia"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6969-4328","authenticated-orcid":false,"given":"Peter H.","family":"Katelaris","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Concord Hospital University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthea L.","family":"Katelaris","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302254"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05911.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02737.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37051"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04937.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00637.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.782286"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00776.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03531.x"},{"key":"e_1_2_6_13_1","first-page":"A205","article-title":"Efficacy of repeat treatments after initial failure of Helicobacter pylori eradication therapy","volume":"116","author":"Katelaris PH","year":"1999","journal-title":"Gastroenterology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12089"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13128"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i46.13073"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00507.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03807.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.06.016"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02522.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.09.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-170"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.796362"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2014.09.037"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.553"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00568.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00971.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80327-8"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13495"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i45.12954"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12258"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1998.tb00660.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.87"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00504.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03573.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/974594"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.198309"},{"volume-title":"Gastric Disorders. Therapeutic Guidelines. Gastrointestinal 2016, Version 6","year":"2016","author":"Katelaris PH","key":"e_1_2_6_39_1"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:40:44Z","timestamp":1695562844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/imj.13432"],"URL":"https:\/\/doi.org\/10.1111\/imj.13432","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"type":"print","value":"1444-0903"},{"type":"electronic","value":"1445-5994"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"2016-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}