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However, the findings that many patients continue to experience events or harbour inappropriately high <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C levels despite intensive statin therapy and the clinical reality of statin intolerance suggests that additional therapeutic strategies are required in order to achieve more effective reductions in cardiovascular risk. The emergence of inhibitory monoclonal antibodies targeted against proprotein convertase subtilisin kexin type 9 (<jats:styled-content style=\"fixed-case\">PCSK9<\/jats:styled-content>) provides a novel approach to reducing <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010C levels. 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