{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:43:18Z","timestamp":1770450198493,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence\u2010based screening tools are required for detection of daytime hypercapnia in high\u2010risk patient populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the validity of supine awake oximetry as a test for daytime hypercapnia and severe sleep disordered breathing (<jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>) in super\u2010obese patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional diagnostic test evaluation of super\u2010obese adults (body mass index &gt;50\u2009kg\/m<jats:sup>2<\/jats:sup>) presenting to Liverpool Hospital, Australia, between 2009 and 2015 for diagnostic polysomnography (<jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content>) and arterial blood gas measurement. Supine awake oxygen saturation (<jats:styled-content style=\"fixed-case\">SpO<jats:sub>2<\/jats:sub><\/jats:styled-content>) was determined using oximetry measurements from the first three awake epochs of raw <jats:styled-content style=\"fixed-case\">PSG<\/jats:styled-content> data. Sensitivity and specificity of <jats:styled-content style=\"fixed-case\">SpO<jats:sub>2<\/jats:sub><\/jats:styled-content> for detecting patients with daytime hypercapnia (<jats:styled-content style=\"fixed-case\">PaCO<jats:sub>2<\/jats:sub><\/jats:styled-content> &gt;45\u2009<jats:styled-content style=\"fixed-case\">mmHg<\/jats:styled-content>) and severe <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content> (respiratory disturbance index (<jats:styled-content style=\"fixed-case\">RDI<\/jats:styled-content>) &gt;30 events\/h) were assessed at various cut\u2010off points and displayed using a receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve. Area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve and positive and negative predictive values (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content>) in the present patient population were derived.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 52 patients, 23 (44%) had daytime hypercapnia. <jats:styled-content style=\"fixed-case\">SpO<jats:sub>2<\/jats:sub><\/jats:styled-content> measured awake in the supine position was associated with the presence of daytime hypercapnia but not with the presence of severe <jats:styled-content style=\"fixed-case\">SDB<\/jats:styled-content>. Overall, awake supine <jats:styled-content style=\"fixed-case\">SpO<jats:sub>2<\/jats:sub><\/jats:styled-content> &lt;91.2% had 34.8% sensitivity, 96.6% specificity and 88.8% <jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SpO<jats:sub>2<\/jats:sub><\/jats:styled-content> &lt;96.7% had 87.0% sensitivity, 20.7% specificity and 66.7% <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> for the presence of daytime hypercapnia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Awake supine oximetry is an easily performed test that may have novel use in identifying patients at high risk of respiratory failure. Future studies are required to evaluate prospectively its role in screening patients at risk of daytime hypercapnia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13496","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T07:50:39Z","timestamp":1496130639000},"page":"1136-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Supine awake oximetry as a screening tool for daytime hypercapnia in super\u2010obese patients"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-6608","authenticated-orcid":false,"given":"Yewon","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Liverpool Hospital  Sydney New South Wales Australia"},{"name":"Respiratory, Sleep and Environmental Health Research Group University of New South Wales  Sydney New South Wales Australia"},{"name":"South Western Sydney Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances L.","family":"Garden","sequence":"additional","affiliation":[{"name":"Respiratory, Sleep and Environmental Health Research Group University of New South Wales  Sydney New South Wales Australia"},{"name":"South Western Sydney Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Ingham Institute of Applied Medical Research  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelle S.","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Central Clinical School University of Sydney  Sydney New South Wales 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