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More than 80% of patients with<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>display evidence of myeloma bone disease (<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content>), characterised by the formation of osteolytic lesions throughout the axial and appendicular skeleton.<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content>significantly increases the risk of skeletal\u2010related events such as pathologic fracture, spinal cord compression and hypercalcaemia.<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content>is the result of<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>plasma cells\u2010mediated activation of osteoclast activity and suppression of osteoblast activity. Bisphosphonates (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>), pyrophosphate analogues with high bone affinity, are the only pharmacological agents currently recommended for the treatment and prevention of<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content>and remain the standard of care. Pamidronate and zoledronic acid are the most commonly used<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>to treat<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content>. Although generally safe, frequent high doses of<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>are associated with adverse events such as renal toxicity and osteonecrosis of the jaw. As such, optimal duration and dosing of<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>therapy is required in order to minimise<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\u2010associated adverse events. The following guidelines provide currently available evidence for the adoption of a tailored approach when using<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>for the management of<jats:styled-content style=\"fixed-case\">MBD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/imj.13502","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T01:30:09Z","timestamp":1502069409000},"page":"938-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Bisphosphonate guidelines for treatment and prevention of myeloma bone disease"],"prefix":"10.1111","volume":"47","author":[{"given":"Oi Lin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Haematology Royal Adelaide Hospital Adelaide South Australia 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