{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:25:09Z","timestamp":1740126309447,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100356","81202093"],"award-info":[{"award-number":["81100356","81202093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clonal Philadelphia (Ph)\u2010negative cytogenetic abnormalities (<jats:styled-content style=\"fixed-case\">CPCA<\/jats:styled-content>) have been reported in chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>) patients treated with either interferon or tyrosine kinase inhibitor (<jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>). However, the incidences and types of these cytogenetic abnormalities after treatment vary due to the limited populations enroled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed the frequency and types of <jats:styled-content style=\"fixed-case\">CPCA<\/jats:styled-content> in a cohort of 607 <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients in the chronic phase after <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> treatment. We also followed up these <jats:styled-content style=\"fixed-case\">CPCA<\/jats:styled-content> with a median of 31.8 months (range from 11 to 63 months) from diagnosis and investigated their effects on disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 18 out of 607 <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients had cytogenetic abnormality in the Ph\u2010negative cells with an incidence of 3%. In total, six types of chromosomal abnormalities have been identified in these 18 patients with the majority of them aneuploidy abnormalities, especially the trisomy 8. Four of 18 patients (22.2%) were noted to have several abnormalities in the Ph\u2010negative cells. Furthermore, follow\u2010up studies of these <jats:styled-content style=\"fixed-case\">CPCA<\/jats:styled-content> showed that they could be either persistent or transient (15 vs 3 patients), and may not affect disease progression since none of them developed transformed myelodysplasia or transformed acute myeloid leukaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three percent of <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients in the chronic phase were observed to have <jats:styled-content style=\"fixed-case\">CPCA<\/jats:styled-content> during <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> treatment. Our results suggest that the detection of <jats:styled-content style=\"fixed-case\">CPCA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> may not predict disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13527","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T11:46:40Z","timestamp":1498045600000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Characterisation of clonal Philadelphia\u2010negative cytogenetic abnormalities in a large cohort of chronic myeloid leukaemia"],"prefix":"10.1111","volume":"48","author":[{"given":"Xiangjun","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Stem Cell Research and Application, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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