{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:38:59Z","timestamp":1769834339054,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T00:00:00Z","timestamp":1507507200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Veneto Region, Italy","award":["497\/2012"],"award-info":[{"award-number":["497\/2012"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Entry criteria included patients who developed sinusoidal obstruction syndrome (SOS<\/jats:styled-content>) at a single centre from January 2000 to December 2011. Patients who underwent haemopoietic stem cell transplantation or actinomicyn\u2010based chemotherapy for nephroblastoma were selected. The study group comprised five patients with SOS<\/jats:styled-content> who were compared with a control group of seven patients without SOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Aim<\/jats:title>To study the relationships between endothelial extracellular vesicles (EV<\/jats:styled-content>) and plasminogen\u2010activator inhibitor type 1(PAI<\/jats:styled-content>\u20101) to assess their modification in the early phase of SOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Consecutive blood samples were tested for cell\u2010derived EV<\/jats:styled-content>, PAI<\/jats:styled-content>\u20101 and coagulation parameters. Any statistically significant correlation between all datasets was searched.<\/jats:p><\/jats:sec>Results<\/jats:title>Antithrombin level and platelet count were statistically significantly reduced in SOS<\/jats:styled-content> patients, suggesting a consumption status. PAI<\/jats:styled-content>\u20101:Ag and PAI<\/jats:styled-content>\u20101:act showed an inverse relationship with platelet counts (coef. \u22120.034, SE<\/jats:styled-content>\u2009=\u20090.016; P<\/jats:italic>\u2009=\u20090.041 and \u22120.052, SE<\/jats:styled-content>\u2009=\u20090.019; P<\/jats:italic>\u2009=\u20090.011 respectively). During follow up, PAI<\/jats:styled-content>\u20101:Ag was inversely related to EV CD144<\/jats:styled-content>+ (coef. \u22120.261, SE<\/jats:styled-content>\u2009=\u20090.094; P<\/jats:italic>\u2009=\u20090.007) and antithrombin (coef \u22120.509, SE<\/jats:styled-content>\u2009=\u20090.175; P<\/jats:italic>\u2009=\u20090.005). PAI<\/jats:styled-content>\u20101:act showed an inverse association with EV CD144<\/jats:styled-content>+ (coef.\u22120.251, SE<\/jats:styled-content>\u2009= 0.121; P<\/jats:italic>\u2009=\u20090.043), EV CD31<\/jats:styled-content>+\/CD41<\/jats:styled-content>+ (coef. \u22120.004, SE<\/jats:styled-content>\u2009=\u20090.002; P<\/jats:italic>\u2009=\u20090.026) and antithrombin (coef. \u22120.470, SE<\/jats:styled-content>\u2009=\u20090.220; P<\/jats:italic>\u2009=\u20090.038). EV<\/jats:styled-content> generated by rupture of gap junctions (EV CD144<\/jats:styled-content>+) were increased in SOS<\/jats:styled-content> patients and also showed a change over time.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study demonstrates the existence of an ongoing procoagulant and hypofibrinolytic status in SOS<\/jats:styled-content>, indicating a possible role for anticoagulant therapy. Moreover, these findings suggest a role for EV CD<\/jats:styled-content> 144+, either alone or in combination with PAI<\/jats:styled-content>\u20101, as a new biomarker for SOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13550","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T09:32:41Z","timestamp":1500024761000},"page":"1173-1183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["New insights into sinusoidal obstruction syndrome"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-8496","authenticated-orcid":false,"given":"Andrea","family":"Piccin","sequence":"first","affiliation":[{"name":"Transfusion Service San Maurizio Regional Hospital Bolzano Italy"},{"name":"Department of Internal Medicine V Medical University Innsbruck Austria"},{"name":"IMREST (Interdisciplinary Medical Research Center South Tyrol) Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Sartori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Medicine Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[{"name":"Oncology Hematology Division, Department of Woman's and Child's Health University of Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Van Schilfgaarde","sequence":"additional","affiliation":[{"name":"Haematology and Clinical Chemistry Laboratory OLVG Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Saggiorato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Medicine Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela M. D.","family":"Pierro","sequence":"additional","affiliation":[{"name":"IMREST (Interdisciplinary Medical Research Center South Tyrol) Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Corvetta","sequence":"additional","affiliation":[{"name":"IMREST (Interdisciplinary Medical Research Center South Tyrol) Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mega","sequence":"additional","affiliation":[{"name":"IMREST (Interdisciplinary Medical Research Center South Tyrol) Bolzano Italy"},{"name":"Gastroenterology Department San Maurizio Regional Hospital Bolzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Gastl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Medical University Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Cesaro","sequence":"additional","affiliation":[{"name":"Paediatric Hematology\u2010Oncology Azienda Ospedaliera Universitaria Integrata Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1072380"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.18"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040121"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819042000219485"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61938-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2184"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.02.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23213"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.ED019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2006.09.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.04.010"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v4.28414"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.930.003k46_930_935"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.12.015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-12-0810"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.06.015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04133.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04758.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360600"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22841"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000632"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.1.220.220"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(88)90177-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2006.03.006"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2017.02.001"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/07474939008800180"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529876"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.25625"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3282f2b5d9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1334.h81602001334_1334_1339"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-011-1376-z"}],"updated-by":[{"DOI":"10.1111\/imj.15305","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000}}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.13550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:25:47Z","timestamp":1693556747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/imj.13550"],"URL":"https:\/\/doi.org\/10.1111\/imj.13550","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/imj.15305","asserted-by":"object"}]},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"2016-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}