{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:37:13Z","timestamp":1790487433060,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pathology Queensland - Study, Education and Research Trust Fund"},{"name":"Australian National Health and Medical Research Council","award":["1083090"],"award-info":[{"award-number":["1083090"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is a common cause of incidental liver test abnormalities. General practitioners (GP) have a key role in identifying people with NAFLD at risk of significant liver disease. Recent specialist guidelines emphasise the use of fibrosis algorithms or serum biomarkers rather than routine liver tests, to assess advanced fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate primary care clinicians\u2019 current approach to diagnosis, management and referral of NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional survey of primary care clinicians was undertaken through a structured questionnaire about NAFLD. A convenience sample of general practice clinics and general practice conferences in Metropolitan Brisbane and regional south east Queensland was selected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 108 primary care clinicians completed the survey (participation rate 100%). Fifty\u2010one percent of respondents considered the prevalence of NAFLD in the general population to be \u226410%. Twenty\u2010four percent of respondents felt that liver enzymes were sufficiently sensitive to detect underlying NAFLD. Most respondents were unsure whether the Fibrosis 4 score (62.7% unsure) or Enhanced Liver Fibrosis score (63.7% unsure) could help to identify advanced fibrosis or cirrhosis. Although 47% of respondents said they would refer a patient to a Gastroenterologist\/Hepatologist if they suspect the patient has NAFLD, 44.1% do not make any referrals. Of concern, 70.6% of clinicians said they were unlikely to refer a patient to Hepatology unless liver function tests are abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings demonstrate that many primary care clinicians underestimate the prevalence of NAFLD and under\u2010recognise the clinical spectrum of NAFLD and how this is assessed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13667","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T11:06:40Z","timestamp":1509361600000},"page":"144-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Underappreciation of non\u2010alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2433-6794","authenticated-orcid":false,"given":"Preya J.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Centre for Liver Disease Research, Translational Research Institute, Faculty of Medicine and Biomedical Science The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Banh","sequence":"additional","affiliation":[{"name":"Centre for Liver Disease Research, Translational Research Institute, Faculty of Medicine and Biomedical Science The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh U.","family":"Horsfall","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Centre for Liver Disease Research, Translational Research Institute, Faculty of Medicine and Biomedical Science The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-3420","authenticated-orcid":false,"given":"Kelly L.","family":"Hayward","sequence":"additional","affiliation":[{"name":"Centre for Liver Disease Research, Translational Research Institute, Faculty of Medicine and Biomedical Science The University of Queensland  Brisbane Queensland Australia"},{"name":"School of Clinical Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrina","family":"Hossain","sequence":"additional","affiliation":[{"name":"Inala Primary Care  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Johnson","sequence":"additional","affiliation":[{"name":"Inala Primary Care  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel N.","family":"Brown","sequence":"additional","affiliation":[{"name":"Pathology Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivene","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Radiology Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Clouston","sequence":"additional","affiliation":[{"name":"Centre for Liver Disease Research, Translational Research Institute, Faculty of Medicine and Biomedical Science The University of Queensland  Brisbane Queensland 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